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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

✇Nature - Issue - nature.com science feeds
By: Hengxing Chen · Yun Li · Huafu Li · Xiancong Chen · Huafeng Fu · Deli Mao · Wei Chen · Linxiang Lan · Chunming Wang · Kaishun Hu · Jia Li · Chengming Zhu · Ian Evans · Eddie Cheung · Daning Lu · Yulong He · Axel Behrens · Dong Yin · Changhua Zhang

Nature, Published online: 03 July 2024; doi:10.1038/s41586-024-07620-9

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.
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Genome-wide characterization of circulating metabolic biomarkers

✇Nature - Issue - nature.com science feeds
By: Minna K. Karjalainen · Savita Karthikeyan · Clare Oliver-Williams · Eeva Sliz · Elias Allara · Wing Tung Fung · Praveen Surendran · Weihua Zhang · Pekka Jousilahti · Kati Kristiansson · Veikko Salomaa · Matt Goodwin · David A. Hughes · Michael Boehnke · Lilian Fernandes Silva · Xianyong Yin · Anubha Mahajan · Matt J. Neville · Natalie R. van Zuydam · Renée de Mutsert · Ruifang Li-Gao · Dennis O. Mook-Kanamori · Ayse Demirkan · Jun Liu · Raymond Noordam · Stella Trompet · Zhengming Chen · Christiana Kartsonaki · Liming Li · Kuang Lin · Fiona A. Hagenbeek · Jouke Jan Hottenga · René Pool · M. Arfan Ikram · Joyce van Meurs · Toomas Haller · Yuri Milaneschi · Mika Kähönen · Pashupati P. Mishra · Peter K. Joshi · Erin Macdonald-Dunlop · Massimo Mangino · Jonas Zierer · Ilhan E. Acar · Carel B. Hoyng · Yara T. E. Lechanteur · Lude Franke · Alexander Kurilshikov · Alexandra Zhernakova · Marian Beekman · Erik B. van den Akker · Ivana Kolcic · Ozren Polasek · Igor Rudan · Christian Gieger · Melanie Waldenberger · Folkert W. Asselbergs · Caroline Hayward · Jingyuan Fu · A

Nature, Published online: 06 March 2024; doi:10.1038/s41586-024-07148-y

A meta-analysis of genome-wide association studies for 233 circulating metabolites from 33 cohorts reveals more than 400 loci and suggests probable causal genes, providing insights into metabolic pathways and disease aetiology.
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SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53

✇Oncogene - Issue - nature.com science feeds
By: Ben Che · Yunyan Du · Rongfa Yuan · Han Xiao · Wenming Zhang · Jun Shao · Hongcheng Lu · Yi Yu · Mingfeng Xiang · Liang Hao · Shouhua Zhang · Xiaohong Du · Xiuxia Liu · Wei Zhou · Kai Wang · Leifeng Chen

Oncogene, Published online: 22 September 2023; doi:10.1038/s41388-023-02843-y

SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53
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