npj Digital Medicine, Published online: 30 August 2025; doi:10.1038/s41746-025-01945-z

Enabling secure and self determined health data sharing and consent management

We developed a plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues. We provide examples showing how to use them in virtual experiments exploring how cancer responds to the cells in its environment and how the brain forms layers in development.

Gemini is Google’s long-promised, next-gen generative AI model family.

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OpenAI used the subreddit, r/ChangeMyView, to create a test for measuring the persuasive abilities of its AI reasoning models. The company revealed this in a system card — a document outlining how an AI system works — that was released along with its new “reasoning” model, o3-mini, on Friday. Millions of Reddit users are members […]

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Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00052-z

The incoming US president is expected to gut support for research on the environment and infectious diseases, but could buoy work in artificial intelligence, quantum research and space exploration.

Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.

Cancer biomarkers have transformed oncology, enabling treatments tailored to each tumor’s unique profile. This review highlights the field’s progress due to advancements in understanding cancer biology, testing methods, and understanding of the immune microenvironment to advance precision oncology for improved patient outcomes.

Nature, Published online: 23 February 2024; doi:10.1038/d41586-024-00568-w

Debate over figure connecting genes, race and ethnicity reignites concerns among geneticists about how to represent human diversity.

Nature, Published online: 08 February 2024; doi:10.1038/s41586-024-07051-6

Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Nature, Published online: 07 December 2023; doi:10.1038/d41586-023-03898-3

The new bargaining group will represent thousands of early-career scientists at the US National Institutes of Health.

Nature, Published online: 06 December 2023; doi:10.1038/d41586-023-03821-w

One organ in a person’s body can age faster than the rest — with implications for health and mortality.

Nature, Published online: 25 October 2023; doi:10.1038/d41586-023-03272-3

A neural-network-based artificial intelligence outperforms ChatGPT at quickly folding new words into its lexicon, a key aspect of human intelligence.

Oncogene, Published online: 24 October 2023; doi:10.1038/s41388-023-02857-6

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption

Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7

A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

Nature, Published online: 05 April 2023; doi:10.1038/d41586-023-00998-y

First peer-reviewed analysis of the Chinese swabs confirms animal DNA was present in samples that tested positive for SARS-CoV-2.

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1

The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.

Nature, Published online: 09 March 2023; doi:10.1038/d41586-023-00717-7

Proof-of-concept mouse experiment will have a long road before use in humans is possible.

Nature, Published online: 16 February 2023; doi:10.1038/d41586-023-00469-4

US regulatory agency makes ‘big change’ to increase the number of participants from under-represented groups in drug testing.

People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...

Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...