A full life cycle biological clock based on routine clinical data and its impact in health and diseases

By: Kai Wang · Fei Liu · Wei Wu · Changxi Hu · Xian Shen · Meihao Wang · Gen Li · Fanxin Zeng · Li Liu · Io Nam Wong · Sian Liu · Zixing Zou · Bingzhou Li · Jinghang Li · Xiaoying Huang · Shengwei Jin · Zhuomin Li · Hui Xu · Gang Chen · Xiaodong Chen · Ying Zhu · Ping Li · Zhe Feng · Winston Wang · Linling Cheng · Mingqi Yang · Qiang Hou · Wenyang Lu · Yiwen Sun · Kun Li · Tian Zhong · Zhuo Sun · Yun Yin · Alexandre Loupy · Eric Oermann · Xiangmei Chen · Kang Zhang · Manson Fok · Taiwa Hou · Lei Guo · Miaosang Xu · Dan Yao · Chengjing Wang · Pingzhen Yang · Caiwen Ou · Xueqiang Wang · Aimin Wu

27 October 2025 at 08:00

Nature Medicine, Published online: 27 October 2025; doi:10.1038/s41591-025-04006-w

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Quality safety and disparity of an AI chatbot in managing chronic diseases: simulated patient experiments

npj Digital Medicine

By: Yafei Si · Yurun Meng · Xi Chen · Ruopeng An · Limin Mao · Bingqin Li · Hazel Bateman · Han Zhang · Hongbin Fan · Jiaqi Zu · Shaoqing Gong · Zhongliang Zhou · Yudong Miao · Xiaojing Fan · Gang Chen

25 September 2025 at 08:00

npj Digital Medicine, Published online: 25 September 2025; doi:10.1038/s41746-025-01956-w

Quality safety and disparity of an AI chatbot in managing chronic diseases: simulated patient experiments

A multi-tissue metabolome atlas of primate pregnancy

Cell

By: Dainan Yu， Haifeng Wan， Chao Tong， Lu Guang， Gang Chen， Jiali Su， Lan Zhang， Yue Wang， Zhenyu Xiao， Jinglei Zhai， Long Yan， Wenwu Ma， Kun Liang， Taoyan Liu， Yuefan Wang， Zehang Peng， Lanfang Luo， Ruoxuan Yu， Wei Li， Hongbo Qi， Hongmei Wang， Ng Shyh-Chang

1 February 2024 at 08:00

A multi-tissue metabolome atlas of 23 maternal tissues from pregnant monkeys revealed dynamic metabolic coupling, core pathways, and a multitude of pregnancy-adaptive metabolites during normal primate pregnancy, with implications for female health.

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