A full life cycle biological clock based on routine clinical data and its impact in health and diseases

By: Kai Wang · Fei Liu · Wei Wu · Changxi Hu · Xian Shen · Meihao Wang · Gen Li · Fanxin Zeng · Li Liu · Io Nam Wong · Sian Liu · Zixing Zou · Bingzhou Li · Jinghang Li · Xiaoying Huang · Shengwei Jin · Zhuomin Li · Hui Xu · Gang Chen · Xiaodong Chen · Ying Zhu · Ping Li · Zhe Feng · Winston Wang · Linling Cheng · Mingqi Yang · Qiang Hou · Wenyang Lu · Yiwen Sun · Kun Li · Tian Zhong · Zhuo Sun · Yun Yin · Alexandre Loupy · Eric Oermann · Xiangmei Chen · Kang Zhang · Manson Fok · Taiwa Hou · Lei Guo · Miaosang Xu · Dan Yao · Chengjing Wang · Pingzhen Yang · Caiwen Ou · Xueqiang Wang · Aimin Wu

27 October 2025 at 08:00

Nature Medicine, Published online: 27 October 2025; doi:10.1038/s41591-025-04006-w

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Reading view

A full life cycle biological clock based on routine clinical data and its impact in health and diseases

SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53