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Chain-of-Scrutiny: Detecting Backdoor Attacks for Large Language Models

arXiv:2406.05948v4 Announce Type: replace-cross Abstract: Large Language Models (LLMs), especially those accessed via APIs, have demonstrated impressive capabilities across various domains. However, users without technical expertise often turn to (untrustworthy) third-party services, such as prompt engineering, to enhance their LLM experience, creating vulnerabilities to adversarial threats like backdoor attacks. Backdoor-compromised LLMs generate malicious outputs to users when inputs contain specific "triggers" set by attackers. Traditional defense strategies, originally designed for small-scale models, are impractical for API-accessible LLMs due to limited model access, high computational costs, and data requirements. To address these limitations, we propose Chain-of-Scrutiny (CoS) which leverages LLMs' unique reasoning abilities to mitigate backdoor attacks. It guides the LLM to generate reasoning steps for a given input and scrutinizes for consistency with the final output -- any inconsistencies indicating a potential attack. It is well-suited for the popular API-only LLM deployments, enabling detection at minimal cost and with little data. User-friendly and driven by natural language, it allows non-experts to perform the defense independently while maintaining transparency. We validate the effectiveness of CoS through extensive experiments on various tasks and LLMs, with results showing greater benefits for more powerful LLMs.
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A full life cycle biological clock based on routine clinical data and its impact in health and diseases

Nature Medicine, Published online: 27 October 2025; doi:10.1038/s41591-025-04006-w

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
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Stop treating code like an afterthought: record, share and value it

Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03196-0

Scientists, research institutions, funders, libraries and publishers must all improve software practices.
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Validation of an AI-enabled exome/transcriptome liquid biopsy platform for early detection, MRD, disease monitoring, and therapy selection for solid tumors

Sci Rep. 2025 Jul 1;15(1):21173. doi: 10.1038/s41598-025-08986-0.

ABSTRACT

Effective clinical management of patients with cancer requires highly accurate diagnosis, precise therapy selection, and highly sensitive monitoring of disease burden. Caris Assure is a multifunctional blood-based assay that couples whole exome and whole transcriptome sequencing on plasma and leukocytes with advanced machine learning techniques to satisfy all three clinical testing needs on one platform. Caris Assure for therapy selection was CLIA validated using 1,910 samples. 376,197 tissue profiles along with 7,061 paired blood and tissue profiles were used to engineer features for three machine learning models. The MCED model was trained on 1,013 patients and validated on an independent set of 2,675 patients. The tissue of origin for MCED model was trained on 1,166 samples and validated using 5-fold cross validation. The MRD & Monitoring model was trained on 3,439 patients and validated on two independent sets of 86 patients for MRD and 101 patients for monitoring. For early detection, sensitivities for stages I-IV cancers (n = 284, 129, 90, 23 respectively) were 83.1%, 86.0%, 84.4%, and 95.7%, all at 99.6% specificity (n = 2149). The diagnostic first-line procedure for tissue of origin was determined for 8 categories with a top-3 accuracy of 85% for stage I and II cancers. Detection of driver mutations for therapy selection from blood collected within 30 days of matched tumor tissue, demonstrated high concordance (PPA of 93.8%, PPV of 96.8%) using CHIP subtraction. For MRD and recurrence monitoring, the disease-free survival of patients whose cancers were predicted to have an event was significantly shorter than those predicted not to have an event using a tumor naïve approach (HR = 33.4, p < 0.005, HR = 4.39, p = 0.008, respectively). The data presented here demonstrate a unified liquid biopsy platform that uses blood-based whole-exome and transcriptome sequencing coupled with artificial intelligence to address the important clinical needs in multi-cancer early detection, monitoring of MRD and recurrent cancers, and precision selection of molecularly targeted therapies.

PMID:40596693 | PMC:PMC12214926 | DOI:10.1038/s41598-025-08986-0

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Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations

Complex disorders require precise strategies for their characterization. AI-based digital phenotypes from biosensors can be used to predict psychiatric disorders and identify GWAS loci.
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