This study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical for ecDNA maintenance in tumor cells. Mechanistic insights into ecDNA replication and maintenance unveil a therapeutic approach for treating tumors harboring ecDNA.

Cell Death Discovery, Published online: 15 June 2024; doi:10.1038/s41420-024-02064-6

The roles of Th cells in myocardial infarction

Oncogenesis, Published online: 04 August 2022; doi:10.1038/s41389-022-00418-2

ZNF655 accelerates progression of pancreatic cancer by promoting the binding of E2F1 and CDK1