arXiv:2601.10718v1 Announce Type: new Abstract: Human papillomavirus (HPV) vaccine hesitancy poses significant public health challenges, particularly in Japan where proactive vaccination recommendations were suspended from 2013 to 2021. The resulting information gap is exacerbated by misinformation on social media, and traditional ways cannot simultaneously address individual queries while monitoring population-level discourse. This study aimed to develop a dual-purpose AI agent system that provides verified HPV vaccine information through a conversational interface while generating analytical reports for medical institutions based on user interactions and social media. We implemented a system comprising: a vector database integrating academic papers, government sources, news media, and social media; a Retrieval-Augmented Generation chatbot using ReAct agent architecture with multi-tool orchestration across five knowledge sources; and an automated report generation system with modules for news analysis, research synthesis, social media sentiment analysis, and user interaction pattern identification. Performance was assessed using a 0-5 scoring scale. For single-turn evaluation, the chatbot achieved mean scores of 4.83 for relevance, 4.89 for routing, 4.50 for reference quality, 4.90 for correctness, and 4.88 for professional identity (overall 4.80). Multi-turn evaluation yielded higher scores: context retention 4.94, topic coherence 5.00, and overall 4.98. The report generation system achieved completeness 4.00-5.00, correctness 4.00-5.00, and helpfulness 3.67-5.00, with reference validity 5.00 across all periods. This study demonstrates the feasibility of an integrated AI agent system for bidirectional HPV vaccine communication. The architecture enables verified information delivery with source attribution while providing systematic public discourse analysis, with a transferable framework for adaptation to other medical contexts.

arXiv:2601.10748v1 Announce Type: cross Abstract: Background: Artificial intelligence enabled electrocardiography (AI-ECG) has demonstrated the ability to detect diverse pathologies, but most existing models focus on single disease identification, neglecting comorbidities and future risk prediction. Although ECGFounder expanded cardiac disease coverage, a holistic health profiling model remains needed. Methods: We constructed a large multicenter dataset comprising 13.3 million ECGs from 2.98 million patients. Using transfer learning, ECGFounder was fine-tuned to develop AnyECG, a foundation model for holistic health profiling. Performance was evaluated using external validation cohorts and a 10-year longitudinal cohort for current diagnosis, future risk prediction, and comorbidity identification. Results: AnyECG demonstrated systemic predictive capability across 1172 conditions, achieving an AUROC greater than 0.7 for 306 diseases. The model revealed novel disease associations, robust comorbidity patterns, and future disease risks. Representative examples included high diagnostic performance for hyperparathyroidism (AUROC 0.941), type 2 diabetes (0.803), Crohn disease (0.817), lymphoid leukemia (0.856), and chronic obstructive pulmonary disease (0.773). Conclusion: The AnyECG foundation model provides substantial evidence that AI-ECG can serve as a systemic tool for concurrent disease detection and long-term risk prediction.

npj Digital Medicine, Published online: 17 January 2026; doi:10.1038/s41746-026-02344-8

Wearable device derived electrocardiographic age and its association with atrial fibrillation

Nature Cancer, Published online: 16 January 2026; doi:10.1038/s43018-025-01110-1

Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cells and the tumor microenvironment.

Nature Medicine, Published online: 16 January 2026; doi:10.1038/s41591-025-04073-z

Analyses of liver biopsies from a child with spinal muscular atrophy treated with adeno-associated virus gene therapy who developed hepatitis reveal contaminating manufacturing plasmids and disrupted vector genomes, possibly resulting from recombination events.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09940-w

In mice, a SPOCD1–TPR-dependent ‘nowhere-to-hide’ mechanism is required for complete non-stochastic piRNA-directed LINE1 DNA methylation by preventing transposons from escaping surveillance within heterochromatin.

npj Digital Medicine, Published online: 13 January 2026; doi:10.1038/s41746-025-02283-w

Enhancing telesurgical safety with predictive digital twin synchronization: a framework for latency compensation in robotic surgery

arXiv:2512.20387v4 Announce Type: replace Abstract: We propose a Vision-Language Simulation Model (VLSM) that unifies visual and textual understanding to synthesize executable FlexScript from layout sketches and natural-language prompts, enabling cross-modal reasoning for industrial simulation systems. To support this new paradigm, the study constructs the first large-scale dataset for generative digital twins, comprising over 120,000 prompt-sketch-code triplets that enable multimodal learning between textual descriptions, spatial structures, and simulation logic. In parallel, three novel evaluation metrics, Structural Validity Rate (SVR), Parameter Match Rate (PMR), and Execution Success Rate (ESR), are proposed specifically for this task to comprehensively evaluate structural integrity, parameter fidelity, and simulator executability. Through systematic ablation across vision encoders, connectors, and code-pretrained language backbones, the proposed models achieve near-perfect structural accuracy and high execution robustness. This work establishes a foundation for generative digital twins that integrate visual reasoning and language understanding into executable industrial simulation systems. Project page: https://danielhsu2014.github.io/GDT-VLSM-project/

A consumer economics watchdog says Google's new Universal Commerce Protocol is ripe for misuse where consumers could pay more for items. Google denies this.

arXiv:2601.06453v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly grounded in sensor data to perceive and reason about human physiology and the physical world. However, accurately interpreting heterogeneous multimodal sensor data remains a fundamental challenge. We show that a single monolithic LLM often fails to reason coherently across modalities, leading to incomplete interpretations and prior-knowledge bias. We introduce ConSensus, a training-free multi-agent collaboration framework that decomposes multimodal sensing tasks into specialized, modality-aware agents. To aggregate agent-level interpretations, we propose a hybrid fusion mechanism that balances semantic aggregation, which enables cross-modal reasoning and contextual understanding, with statistical consensus, which provides robustness through agreement across modalities. While each approach has complementary failure modes, their combination enables reliable inference under sensor noise and missing data. We evaluate ConSensus on five diverse multimodal sensing benchmarks, demonstrating an average accuracy improvement of 7.1% over the single-agent baseline. Furthermore, ConSensus matches or exceeds the performance of iterative multi-agent debate methods while achieving a 12.7 times reduction in average fusion token cost through a single-round hybrid fusion protocol, yielding a robust and efficient solution for real-world multimodal sensing tasks.

arXiv:2601.06663v1 Announce Type: new Abstract: Large language model-based agents are rapidly evolving from simple conversational assistants into autonomous systems capable of performing complex, professional-level tasks in various domains. While these advancements promise significant productivity gains, they also introduce critical safety risks that remain under-explored. Existing safety evaluations primarily focus on simple, daily assistance tasks, failing to capture the intricate decision-making processes and potential consequences of misaligned behaviors in professional settings. To address this gap, we introduce \textbf{SafePro}, a comprehensive benchmark designed to evaluate the safety alignment of AI agents performing professional activities. SafePro features a dataset of high-complexity tasks across diverse professional domains with safety risks, developed through a rigorous iterative creation and review process. Our evaluation of state-of-the-art AI models reveals significant safety vulnerabilities and uncovers new unsafe behaviors in professional contexts. We further show that these models exhibit both insufficient safety judgment and weak safety alignment when executing complex professional tasks. In addition, we investigate safety mitigation strategies for improving agent safety in these scenarios and observe encouraging improvements. Together, our findings highlight the urgent need for robust safety mechanisms tailored to the next generation of professional AI agents.

arXiv:2601.07463v1 Announce Type: new Abstract: Offline multi-agent reinforcement learning (MARL) aims to solve cooperative decision-making problems in multi-agent systems using pre-collected datasets. Existing offline MARL methods primarily constrain training within the dataset distribution, resulting in overly conservative policies that struggle to generalize beyond the support of the data. While model-based approaches offer a promising solution by expanding the original dataset with synthetic data generated from a learned world model, the high dimensionality, non-stationarity, and complexity of multi-agent systems make it challenging to accurately estimate the transitions and reward functions in offline MARL. Given the difficulty of directly modeling joint dynamics, we propose a local-to-global (LOGO) world model, a novel framework that leverages local predictions-which are easier to estimate-to infer global state dynamics, thus improving prediction accuracy while implicitly capturing agent-wise dependencies. Using the trained world model, we generate synthetic data to augment the original dataset, expanding the effective state-action space. To ensure reliable policy learning, we further introduce an uncertainty-aware sampling mechanism that adaptively weights synthetic data by prediction uncertainty, reducing approximation error propagation to policies. In contrast to conventional ensemble-based methods, our approach requires only an additional encoder for uncertainty estimation, significantly reducing computational overhead while maintaining accuracy. Extensive experiments across 8 scenarios against 8 baselines demonstrate that our method surpasses state-of-the-art baselines on standard offline MARL benchmarks, establishing a new model-based baseline for generalizable offline multi-agent learning.

arXiv:2601.06060v1 Announce Type: cross Abstract: AI-generated "slop" is often seen as digital pollution. We argue that this dismissal of the topic risks missing important aspects of AI Slop that deserve rigorous study. AI Slop serves a social function: it offers a supply-side solution to a variety of problems in cultural and economic demand - that, collectively, people want more content than humans can supply. We also argue that AI Slop is not mere digital detritus but has its own aesthetic value. Like other "low" cultural forms initially dismissed by critics, it nonetheless offers a legitimate means of collective sense-making, with the potential to express meaning and identity. We identify three key features of family resemblance for prototypical AI Slop: superficial competence (its veneer of quality is belied by a deeper lack of substance), asymmetry effort (it takes vastly less effort to generate than would be the case without AI), and mass producibility (it is part of a digital ecosystem of widespread generation and consumption). While AI Slop is heterogeneous and depends crucially on its medium, it tends to vary across three dimensions: instrumental utility, personalization, and surrealism. AI Slop will be an increasingly prolific and impactful part of our creative, information, and cultural economies; we should take it seriously as an object of study in its own right.

arXiv:2601.07344v1 Announce Type: cross Abstract: Recent advances in medical multi-modal models focus on specialized image analysis like dermatology, pathology, or radiology. However, they do not fully capture the complexity of real-world clinical diagnostics, which involve heterogeneous inputs and require ongoing contextual understanding during patient-physician interactions. To bridge this gap, we introduce PulseMind, a new family of multi-modal diagnostic models that integrates a systematically curated dataset, a comprehensive evaluation benchmark, and a tailored training framework. Specifically, we first construct a diagnostic dataset, MediScope, which comprises 98,000 real-world multi-turn consultations and 601,500 medical images, spanning over 10 major clinical departments and more than 200 sub-specialties. Then, to better reflect the requirements of real-world clinical diagnosis, we develop the PulseMind Benchmark, a multi-turn diagnostic consultation benchmark with a four-dimensional evaluation protocol comprising proactiveness, accuracy, usefulness, and language quality. Finally, we design a training framework tailored for multi-modal clinical diagnostics, centered around a core component named Comparison-based Reinforcement Policy Optimization (CRPO). Compared to absolute score rewards, CRPO uses relative preference signals from multi-dimensional com-parisons to provide stable and human-aligned training guidance. Extensive experiments demonstrate that PulseMind achieves competitive performance on both the diagnostic consultation benchmark and public medical benchmarks.

arXiv:2505.19562v2 Announce Type: replace Abstract: Large language models (LLMs) are approaching expert-level performance in medical question answering (QA), demonstrating strong potential to improve public healthcare. However, underlying biases related to sensitive attributes such as sex and race pose life-critical risks. The extent to which such sensitive attributes affect diagnosis remains an open question and requires comprehensive empirical investigation. Additionally, even the latest Counterfactual Patient Variations (CPV) benchmark can hardly distinguish the bias levels of different LLMs. To further explore these dynamics, we propose a new benchmark, FairMedQA, and benchmark 12 representative LLMs. FairMedQA contains 4,806 counterfactual question pairs constructed from 801 clinical vignettes. Our results reveal substantial accuracy disparity ranging from 3 to 19 percentage points across sensitive demographic groups. Notably, FairMedQA exposes biases that are at least 12 percentage points larger than those identified by the latest CPV benchmark, presenting superior benchmarking sensitivity. Our results underscore an urgent need for targeted debiasing techniques and more rigorous, identity-aware validation protocols before LLMs can be safely integrated into practical clinical decision-support systems.

arXiv:2512.20387v3 Announce Type: replace Abstract: We propose a Vision-Language Simulation Model (VLSM) that unifies visual and textual understanding to synthesize executable FlexScript from layout sketches and natural-language prompts, enabling cross-modal reasoning for industrial simulation systems. To support this new paradigm, the study constructs the first large-scale dataset for generative digital twins, comprising over 120,000 prompt-sketch-code triplets that enable multimodal learning between textual descriptions, spatial structures, and simulation logic. In parallel, three novel evaluation metrics, Structural Validity Rate (SVR), Parameter Match Rate (PMR), and Execution Success Rate (ESR), are proposed specifically for this task to comprehensively evaluate structural integrity, parameter fidelity, and simulator executability. Through systematic ablation across vision encoders, connectors, and code-pretrained language backbones, the proposed models achieve near-perfect structural accuracy and high execution robustness. This work establishes a foundation for generative digital twins that integrate visual reasoning and language understanding into executable industrial simulation systems. Project page: https://danielhsu2014.github.io/GDT-VLSM-project/

Nature Medicine, Published online: 12 January 2026; doi:10.1038/s41591-025-04126-3

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

arXiv:2601.05529v1 Announce Type: new Abstract: One mistake by an AI system in a safety-critical setting can cost lives. As Large Language Models (LLMs) become integral to robotics decision-making, the physical dimension of risk grows; a single wrong instruction can directly endanger human safety. This paper addresses the urgent need to systematically evaluate LLM performance in scenarios where even minor errors are catastrophic. Through a qualitative evaluation of a fire evacuation scenario, we identified critical failure cases in LLM-based decision-making. Based on these, we designed seven tasks for quantitative assessment, categorized into: Complete Information, Incomplete Information, and Safety-Oriented Spatial Reasoning (SOSR). Complete information tasks utilize ASCII maps to minimize interpretation ambiguity and isolate spatial reasoning from visual processing. Incomplete information tasks require models to infer missing context, testing for spatial continuity versus hallucinations. SOSR tasks use natural language to evaluate safe decision-making in life-threatening contexts. We benchmark various LLMs and Vision-Language Models (VLMs) across these tasks. Beyond aggregate performance, we analyze the implications of a 1% failure rate, highlighting how "rare" errors escalate into catastrophic outcomes. Results reveal serious vulnerabilities: several models achieved a 0% success rate in ASCII navigation, while in a simulated fire drill, models instructed robots to move toward hazardous areas instead of emergency exits. Our findings lead to a sobering conclusion: current LLMs are not ready for direct deployment in safety-critical systems. A 99% accuracy rate is dangerously misleading in robotics, as it implies one out of every hundred executions could result in catastrophic harm. We demonstrate that even state-of-the-art models cannot guarantee safety, and absolute reliance on them creates unacceptable risks.

Nature Medicine, Published online: 09 January 2026; doi:10.1038/s41591-025-04170-z

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.