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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

✇Nature - Issue - nature.com science feeds
By: Hengxing Chen · Yun Li · Huafu Li · Xiancong Chen · Huafeng Fu · Deli Mao · Wei Chen · Linxiang Lan · Chunming Wang · Kaishun Hu · Jia Li · Chengming Zhu · Ian Evans · Eddie Cheung · Daning Lu · Yulong He · Axel Behrens · Dong Yin · Changhua Zhang

Nature, Published online: 03 July 2024; doi:10.1038/s41586-024-07620-9

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.
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Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

✇Nature - Issue - nature.com science feeds
By: Siwei Chen · Laurent C. Francioli · Julia K. Goodrich · Ryan L. Collins · Masahiro Kanai · Qingbo Wang · Jessica Alföldi · Nicholas A. Watts · Christopher Vittal · Laura D. Gauthier · Timothy Poterba · Michael W. Wilson · Yekaterina Tarasova · William Phu · Riley Grant · Mary T. Yohannes · Zan Koenig · Yossi Farjoun · Eric Banks · Stacey Donnelly · Stacey Gabriel · Namrata Gupta · Steven Ferriera · Charlotte Tolonen · Sam Novod · Louis Bergelson · David Roazen · Valentin Ruano-Rubio · Miguel Covarrubias · Christopher Llanwarne · Nikelle Petrillo · Gordon Wade · Thibault Jeandet · Ruchi Munshi · Kathleen Tibbetts · Maria Abreu · Carlos A. Aguilar Salinas · Tariq Ahmad · Christine M. Albert · Diego Ardissino · Irina M. Armean · Elizabeth G. Atkinson · Gil Atzmon · John Barnard · Samantha M. Baxter · Laurent Beaugerie · Emelia J. Benjamin · David Benjamin · Michael Boehnke · Lori L. Bonnycastle · Erwin P. Bottinger · Donald W. Bowden · Matthew J. Bown · Harrison Brand · Steven Brant · Ted Brookings · Sam Bryant · Sarah E. Calvo · Hannia Campos · John C. Chambers · Juli

Nature, Published online: 15 January 2024; doi:10.1038/s41586-024-07050-7

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
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Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

✇Cell
By: Haiwei Chen， Connor E. Rosen， Jaime A. González-Hernández， Deguang Song， Jan Potempa， Aaron M. Ring， Noah W. Palm
PRESTO-Salsa is a multiplexed GPCR screening platform that enables the interrogation of GPCRome-wide bioactivities across diverse sample types. This platform was used to explore microbiota-induced GPCR activation and revealed the engagement of an immune cell-associated GPCR by a periodontal pathogen protease.
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Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers

✇Most Recent Articles: Clinical Epigenetics
By: Xin Yang， Xiaofeng Wen， Qin Guo， Yunfeng Zhang， Zhenxing Liang， Qian Wu， Zhihao Li， Weimei Ruan， Zhujia Ye， Hong Wang， Zhiwei Chen， Jian-Bing Fan， Ping Lan， Huashan Liu and Xianrui Wu
Recurrence represents a well-known poor prognostic factor for colorectal cancer (CRC) patients. This study aimed to establish an effective prognostic prediction model based on noninvasive circulating tumor DNA...
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Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p

✇Cell Death Discovery nature.com science feeds
By: Meng Ding · Xiaozhi Zhao · Xiaoqing Chen · Wenli Diao · Yansheng Kan · Wenmin Cao · Wei Chen · Bo Jiang · Haixiang Qin · Jie Gao · Junlong Zhuang · Qing Zhang · Hongqian Guo

Cell Death Discovery, Published online: 01 November 2022; doi:10.1038/s41420-022-01219-7

Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p
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