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Cancer epigenetics: from laboratory studies and clinical trials to precision medicine

Cell Death Discovery nature.com science feeds

By: Xinyang Yu · Hao Zhao · Ruiqi Wang · Yingyin Chen · Xumei Ouyang · Wenting Li · Yihao Sun · Anghui Peng

15 January 2024 at 08:00

Cell Death Discovery, Published online: 15 January 2024; doi:10.1038/s41420-024-01803-z

Cancer epigenetics: from laboratory studies and clinical trials to precision medicine

Histone demethylase KDM5D upregulation drives sex differences in colon cancer

Nature - Issue - nature.com science feeds

By: Jiexi Li · Zhengdao Lan · Wenting Liao · James W. Horner · Xueping Xu · Jielin Liu · Yohei Yoshihama · Shan Jiang · Hong Seok Shim · Max Slotnik · Kyle A. LaBella · Chang-Jiun Wu · Kenneth Dunner Jr. · Wen-Hao Hsu · Rumi Lee · Isha Khanduri · Christopher Terranova · Kadi

21 June 2023 at 08:00

Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7

A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.