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Single-cell multiplex chromatin and RNA interactions in ageing human brain

Nature, Published online: 27 March 2024; doi:10.1038/s41586-024-07239-w

We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.
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Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS

Nature Biotechnology, Published online: 23 January 2024; doi:10.1038/s41587-023-02040-y

Single-cell, multiomic datasets are integrated using dimensionality reduction, imputation and batch correction.
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