Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.

Nature, Published online: 26 June 2024; doi:10.1038/s41586-024-07552-4

A bispecific non-coding RNA expressed by the IS110 family of mobile genetic elements forms the basis of a programmable genome-editing system that enables the insertion, excision or inversion of specific target DNA sequences.

DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.

Oncogene, Published online: 08 May 2024; doi:10.1038/s41388-024-03054-9

A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance

Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-z

Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer

Cell Death Discovery, Published online: 05 April 2024; doi:10.1038/s41420-024-01933-4

Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells

Cancer is a systemic disease in more than one dimension, in terms of its evolutionary course, direct crosstalk with the microenvironment, and intricate communication with the macro-environment. This broad perspective encompasses our understanding of cancer’s systemic features, mapping out the path for tackling its complexity to bridge what we can learn and who we need to help.

Nature, Published online: 27 March 2024; doi:10.1038/s41586-024-07239-w

We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.

Nature, Published online: 13 March 2024; doi:10.1038/s41586-024-07177-7

We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

Immunotherapy holds strong promise for cancer treatment but at present benefits only a small proportion of cases. A pan-cancer analysis of the immune landscape in more than 1,000 tumors across ten cancer types reveals immune surveillance and immune evasion mechanisms as well as potential molecular target that could augment future immunotherapy and precision medicine strategies.

Nature, Published online: 14 February 2024; doi:10.1038/s41586-024-07060-5

Circular RNAs are exported from the nucleus by Ran-GTP, exportin-2 and IGF2BP1 in a mechanism analogous to protein export rather than mRNA export.

Nature, Published online: 08 February 2024; doi:10.1038/s41586-024-07051-6

Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Nature, Published online: 31 January 2024; doi:10.1038/d41586-024-00079-8

Genetic sequencing data from more than 4,000 Chinese participants in the Born in Guangzhou Cohort Study provide insights into the population, and a snapshot of what is to come in future phases of the project.

Nature Biotechnology, Published online: 26 January 2024; doi:10.1038/s41587-023-02100-3

Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy

Nature Biotechnology, Published online: 25 January 2024; doi:10.1038/s41587-023-02107-w

Computationally designed sensors map the activity and signaling environment of Ras.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essen...

Nature, Published online: 15 January 2024; doi:10.1038/s41586-024-07050-7

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and illustrate the potential of this knowledge to identify new SCLC vulnerabilities.

Nature, Published online: 06 December 2023; doi:10.1038/s41586-023-06802-1

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.

An analytical resource of post-translational modifications from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new therapeutic avenues.