Nature Biotechnology, Published online: 10 August 2023; doi:10.1038/s41587-023-01900-x

The function of single-nucleotide variants can now be tested in a base editor mouse model.

Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7

A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved through research advancing on: pore efficiency, creating mechanisms to control DNA transloca...