LangChain has released Open SWE, a fully open-source, asynchronous coding agent designed to operate in the cloud and handle complex software development tasks. The company says Open SWE represents a shift away from real-time “copilot” assistants toward more autonomous, long-running agents that integrate directly with a developer’s existing workflows.

By Robert Krzaczyński

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09398-w

A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study metastasis trajectories.