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A full life cycle biological clock based on routine clinical data and its impact in health and diseases

βœ‡Nature Medicine
By: Kai Wang Β· Fei Liu Β· Wei Wu Β· Changxi Hu Β· Xian Shen Β· Meihao Wang Β· Gen Li Β· Fanxin Zeng Β· Li Liu Β· Io Nam Wong Β· Sian Liu Β· Zixing Zou Β· Bingzhou Li Β· Jinghang Li Β· Xiaoying Huang Β· Shengwei Jin Β· Zhuomin Li Β· Hui Xu Β· Gang Chen Β· Xiaodong Chen Β· Ying Zhu Β· Ping Li Β· Zhe Feng Β· Winston Wang Β· Linling Cheng Β· Mingqi Yang Β· Qiang Hou Β· Wenyang Lu Β· Yiwen Sun Β· Kun Li Β· Tian Zhong Β· Zhuo Sun Β· Yun Yin Β· Alexandre Loupy Β· Eric Oermann Β· Xiangmei Chen Β· Kang Zhang Β· Manson Fok Β· Taiwa Hou Β· Lei Guo Β· Miaosang Xu Β· Dan Yao Β· Chengjing Wang Β· Pingzhen Yang Β· Caiwen Ou Β· Xueqiang Wang Β· Aimin Wu

Nature Medicine, Published online: 27 October 2025; doi:10.1038/s41591-025-04006-w

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
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