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Case Study: Transformer-Based Solution for the Automatic Digitization of Gas Plants

arXiv:2511.08609v1 Announce Type: cross Abstract: The energy transition is a key theme of the last decades to determine a future of eco-sustainability, and an area of such importance cannot disregard digitization, innovation and the new technological tools available. This is the context in which the Generative Artificial Intelligence models described in this paper are positioned, developed by Engineering Ingegneria Informatica SpA in order to automate the plant structures acquisition of SNAM energy infrastructure, a leading gas transportation company in Italy and Europe. The digitization of a gas plant consists in registering all its relevant information through the interpretation of the related documentation. The aim of this work is therefore to design an effective solution based on Artificial Intelligence techniques to automate the extraction of the information necessary for the digitization of a plant, in order to streamline the daily work of MGM users. The solution received the P&ID of the plant as input, each one in pdf format, and uses OCR, Vision LLM, Object Detection, Relational Reasoning and optimization algorithms to return an output consisting of two sets of information: a structured overview of the relevant design data and the hierarchical framework of the plant. To achieve convincing results, we extend a state-of-the-art model for Scene Graph Generation introducing a brand new Transformer architecture with the aim of deepening the analysis of the complex relations between the plant's components. The synergistic use of the listed AI-based technologies allowed to overcome many obstacles arising from the high variety of data, due to the lack of standardization. An accuracy of 91\% has been achieved in the extraction of textual information relating to design data. Regarding the plants topology, 93\% of components are correctly identified and the hierarchical structure is extracted with an accuracy around 80\%.
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Benevolent Dictators? On LLM Agent Behavior in Dictator Games

arXiv:2511.08721v1 Announce Type: cross Abstract: In behavioral sciences, experiments such as the ultimatum game are conducted to assess preferences for fairness or self-interest of study participants. In the dictator game, a simplified version of the ultimatum game where only one of two players makes a single decision, the dictator unilaterally decides how to split a fixed sum of money between themselves and the other player. Although recent studies have explored behavioral patterns of AI agents based on Large Language Models (LLMs) instructed to adopt different personas, we question the robustness of these results. In particular, many of these studies overlook the role of the system prompt - the underlying instructions that shape the model's behavior - and do not account for how sensitive results can be to slight changes in prompts. However, a robust baseline is essential when studying highly complex behavioral aspects of LLMs. To overcome previous limitations, we propose the LLM agent behavior study (LLM-ABS) framework to (i) explore how different system prompts influence model behavior, (ii) get more reliable insights into agent preferences by using neutral prompt variations, and (iii) analyze linguistic features in responses to open-ended instructions by LLM agents to better understand the reasoning behind their behavior. We found that agents often exhibit a strong preference for fairness, as well as a significant impact of the system prompt on their behavior. From a linguistic perspective, we identify that models express their responses differently. Although prompt sensitivity remains a persistent challenge, our proposed framework demonstrates a robust foundation for LLM agent behavior studies. Our code artifacts are available at https://github.com/andreaseinwiller/LLM-ABS.
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AgentFlux: Decoupled Fine-Tuning & Inference for On-Device Agentic Systems

arXiv:2510.00229v4 Announce Type: replace Abstract: The deployment of Large Language Models (LLMs) as agentic orchestrators has revolutionized task automation, but the need for privacy-preserving, cost-effective solutions demands on-device inference capabilities. However, local LLMs consistently underperform compared to frontier models in tool calling scenarios, struggling with both tool selection from large tool sets and accurate argument generation for complex parameter structures. We introduce a methodology that disaggregates a tool-calling task into two distinct subtasks: tool selection and argument generation. We propose "decoupled fine-tuning", a novel post-training approach that employs LoRA fine-tuning to create dedicated LoRA adapters for tool selection and tool-specific argument generation using separate loss masking for each of the subtasks. Furthermore, we present AgentFlux, an inference framework that leverages the LoRA adapters created using decoupled fine-tuning to perform efficient agent orchestration with the help of local models on end-user devices. AgentFlux decomposes the tool-call generation step into tool selection and argument generation, and dynamically loads the corresponding LoRA adapters to generate tool calls. Additionally, AgentFlux implements hierarchical orchestration to restrict the number of tools required for tool selection. Our experiments on the MCP-Bench benchmark demonstrate that the Qwen-2.5-7B model trained using decoupled fine-tuning improves the tool calling accuracy of the base model by 46%, and outperforms other local reasoning, non-reasoning and fine-tuned models of similar size in all cases, and models that are 2x larger, in most cases.
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LLM4AD: Large Language Models for Autonomous Driving - Concept, Review, Benchmark, Experiments, and Future Trends

arXiv:2410.15281v4 Announce Type: replace-cross Abstract: With the broader adoption and highly successful development of Large Language Models (LLMs), there has been growing interest and demand for applying LLMs to autonomous driving technology. Driven by their natural language understanding and reasoning capabilities, LLMs have the potential to enhance various aspects of autonomous driving systems, from perception and scene understanding to interactive decision-making. In this paper, we first introduce the novel concept of designing Large Language Models for Autonomous Driving (LLM4AD), followed by a review of existing LLM4AD studies. Then, we propose a comprehensive benchmark for evaluating the instruction-following and reasoning abilities of LLM4AD systems, which includes LaMPilot-Bench, CARLA Leaderboard 1.0 Benchmark in simulation and NuPlanQA for multi-view visual question answering. Furthermore, we conduct extensive real-world experiments on autonomous vehicle platforms, examining both on-cloud and on-edge LLM deployment for personalized decision-making and motion control. Next, we explore the future trends of integrating language diffusion models into autonomous driving, exemplified by the proposed ViLaD (Vision-Language Diffusion) framework. Finally, we discuss the main challenges of LLM4AD, including latency, deployment, security and privacy, safety, trust and transparency, and personalization.
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Asking the Right Questions: Benchmarking Large Language Models in the Development of Clinical Consultation Templates

arXiv:2508.01159v2 Announce Type: replace-cross Abstract: This study evaluates the capacity of large language models (LLMs) to generate structured clinical consultation templates for electronic consultation. Using 145 expert-crafted templates developed and routinely used by Stanford's eConsult team, we assess frontier models -- including o3, GPT-4o, Kimi K2, Claude 4 Sonnet, Llama 3 70B, and Gemini 2.5 Pro -- for their ability to produce clinically coherent, concise, and prioritized clinical question schemas. Through a multi-agent pipeline combining prompt optimization, semantic autograding, and prioritization analysis, we show that while models like o3 achieve high comprehensiveness (up to 92.2\%), they consistently generate excessively long templates and fail to correctly prioritize the most clinically important questions under length constraints. Performance varies across specialties, with significant degradation in narrative-driven fields such as psychiatry and pain medicine. Our findings demonstrate that LLMs can enhance structured clinical information exchange between physicians, while highlighting the need for more robust evaluation methods that capture a model's ability to prioritize clinically salient information within the time constraints of real-world physician communication.
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Early Detection of Lung Cancer: A Review of Innovative Milestones and Techniques

J Clin Med. 2025 Nov 3;14(21):7812. doi: 10.3390/jcm14217812.

ABSTRACT

Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer death worldwide. Early detection of lung cancer can lead to identification of the cancer at its initial treatable stages and improves survival. Low-dose CT scan (LDCT) is currently the gold standard for lung cancer screening in high-risk individuals. Despite the observed stage migration and consistently demonstrated disease-specific overall survival benefit, LDCT has inherent limitations, including false-positive results, radiation exposure, and low compliance. Recently, new techniques have been investigated for early detection of lung cancer. Several studies have shown that liquid biopsy biomarkers such as circulating cell-free DNA (cfDNA), microRNA molecules (miRNA), circulating tumor cells (CTCs), tumor-derived exosomes (TDEs), and tumor-educated platelets (TEPs), as well as volatile organic compounds (VOCs), have the power to distinguish lung cancer patients from healthy subjects, offering potential for minimally invasive and non-invasive means of early cancer detection. Furthermore, recent studies have shown that the integration of artificial intelligence (AI) with clinical, imaging, and laboratory data has provided significant advancements and can offer potential solutions to some challenges related to early detection of lung cancer. Adopting AI-based multimodality strategies, such as multi-omics liquid biopsy and/or VOCs' detection, with LDCT augmented by advanced AI, could revolutionize early lung cancer screening by improving accuracy, efficiency, and personalization, especially when combined with patient clinical data. However, challenges remain in validating, standardizing, and integrating these approaches into clinical practice. In this review, we described these innovative milestones and methods, as well as their advantages and limitations in screening and early diagnosis of lung cancer.

PMID:41227214 | PMC:PMC12609116 | DOI:10.3390/jcm14217812

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Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution

Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune repertoires in situ.
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Google is still aiming for its “moonshot” 2030 energy goals

Last week, we hosted EmTech MIT, MIT Technology Review’s annual flagship conference in Cambridge, Massachusetts. Over the course of three days of main-stage sessions, I learned about innovations in AI, biotech, and robotics. 

But as you might imagine, some of this climate reporter’s favorite moments came in the climate sessions. I was listening especially closely to my colleague James Temple’s discussion with Lucia Tian, head of advanced energy technologies at Google. 

They spoke about the tech giant’s growing energy demand and what sort of technologies the company is looking to to help meet it. In case you weren’t able to join us, let’s dig into that session and consider how the company is thinking about energy in the face of AI’s rapid rise. 

I’ve been closely following Google’s work in energy this year. Like the rest of the tech industry, the company is seeing ballooning electricity demand in its data centers. That could get in the way of a major goal that Google has been talking about for years. 

See, back in 2020, the company announced an ambitious target: by 2030, it aimed to run on carbon-free energy 24-7. Basically, that means Google would purchase enough renewable energy on the grids where it operates to meet its entire electricity demand, and the purchases would match up so the electricity would have to be generated when the company was actually using energy. (For more on the nuances of Big Tech’s renewable-energy pledges, check out James’s piece from last year.)

Google’s is an ambitious goal, and on stage, Tian said that the company is still aiming for it but acknowledged that it’s looking tough with the rise of AI. 

“It was always a moonshot,” she said. “It’s something very, very hard to achieve, and it’s only harder in the face of this growth. But our perspective is, if we don’t move in that direction, we’ll never get there.”

Google’s total electricity demand more than doubled from 2020 to 2024, according to its latest Environmental Report. As for that goal of 24-7 carbon-free energy? The company is basically treading water. While it was at 67% for its data centers in 2020, last year it came in at 66%. 

Not going backwards is something of an accomplishment, given the rapid growth in electricity demand. But it still leaves the company some distance away from its finish line.

To close the gap, Google has been signing what feels like constant deals in the energy space. Two recent announcements that Tian talked about on stage were a project involving carbon capture and storage at a natural-gas plant in Illinois and plans to reopen a shuttered nuclear power plant in Iowa. 

Let’s start with carbon capture. Google signed an agreement to purchase most of the electricity from a new natural-gas plant, which will capture and store about 90% of its carbon dioxide emissions. 

That announcement was controversial, with critics arguing that carbon capture keeps fossil-fuel infrastructure online longer and still releases greenhouse gases and other pollutants into the atmosphere. 

One question that James raised on stage: Why build a new natural-gas plant rather than add equipment to an already existing facility? Tacking on equipment to an operational plant would mean cutting emissions from the status quo, rather than adding entirely new fossil-fuel infrastructure. 

The company did consider many existing plants, Tian said. But, as she put it, “Retrofits aren’t going to make sense everywhere.” Space can be limited at existing plants, for example, and many may not have the right geology to store carbon dioxide underground. 

“We wanted to lead with a project that could prove this technology at scale,” Tian said. This site has an operational Class VI well, the type used for permanent sequestration, she added, and it also doesn’t require a big pipeline buildout. 

Tian also touched on the company’s recent announcement that it’s collaborating with NextEra Energy to reopen Duane Arnold Energy Center, a nuclear power plant in Iowa. The company will purchase electricity from that plant, which is scheduled to reopen in 2029. 

As I covered in a story earlier this year, Duane Arnold was basically the final option in the US for companies looking to reopen shuttered nuclear power plants. “Just a few years back, we were still closing down nuclear plants in this country,” Tian said on stage. 

While each reopening will look a little different, Tian highlighted the groups working to restart the Palisades plant in Michigan, which was the first reopening to be announced, last spring. “They’re the real heroes of the story,” she said.

I’m always interested to get a peek behind the curtain at how Big Tech is thinking about energy. I’m skeptical but certainly interested to see how Google’s, and the rest of the industry’s, goals shape up over the next few years. 

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.

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