arXiv:2512.14640v1 Announce Type: cross Abstract: Timely and accurate lymphoma diagnosis is essential for guiding cancer treatment. Standard diagnostic practice combines hematoxylin and eosin (HE)-stained whole slide images with immunohistochemistry, flow cytometry, and molecular genetic tests to determine lymphoma subtypes, a process requiring costly equipment, skilled personnel, and causing treatment delays. Deep learning methods could assist pathologists by extracting diagnostic information from routinely available HE-stained slides, yet comprehensive benchmarks for lymphoma subtyping on multicenter data are lacking. In this work, we present the first multicenter lymphoma benchmarking dataset covering four common lymphoma subtypes and healthy control tissue. We systematically evaluate five publicly available pathology foundation models (H-optimus-1, H0-mini, Virchow2, UNI2, Titan) combined with attention-based (AB-MIL) and transformer-based (TransMIL) multiple instance learning aggregators across three magnifications (10x, 20x, 40x). On in-distribution test sets, models achieve multiclass balanced accuracies exceeding 80% across all magnifications, with all foundation models performing similarly and both aggregation methods showing comparable results. The magnification study reveals that 40x resolution is sufficient, with no performance gains from higher resolutions or cross-magnification aggregation. However, on out-of-distribution test sets, performance drops substantially to around 60%, highlighting significant generalization challenges. To advance the field, larger multicenter studies covering additional rare lymphoma subtypes are needed. We provide an automated benchmarking pipeline to facilitate such future research.

arXiv:2512.12791v2 Announce Type: replace-cross Abstract: Recent advances in agentic AI have shifted the focus from standalone Large Language Models (LLMs) to integrated systems that combine LLMs with tools, memory, and other agents to perform complex tasks. These multi-agent architectures enable coordinated reasoning, planning, and execution across diverse domains, allowing agents to collaboratively automate complex workflows. Despite these advances, evaluation and assessment of LLM agents and the multi-agent systems they constitute remain a fundamental challenge. Although various approaches have been proposed in the software engineering literature for evaluating conventional software components, existing methods for AI-based systems often overlook the non-deterministic nature of models. This non-determinism introduces behavioral uncertainty during execution, yet existing evaluations rely on binary task completion metrics that fail to capture it. Evaluating agentic systems therefore requires examining additional dimensions, including the agent ability to invoke tools, ingest and retrieve memory, collaborate with other agents, and interact effectively with its environment. These challenges emerged during our ongoing industry collaboration with MontyCloud Inc., when we deployed an agentic system in production. These limitations surfaced during deployment, highlighting practical gaps in the current evaluation methods and the need for a systematic assessment of agent behavior beyond task outcomes. Informed by these observations and established definitions of agentic systems, we propose an end-to-end Agent Assessment Framework with four evaluation pillars encompassing LLMs, Memory, Tools, and Environment. We validate the framework on a representative Autonomous CloudOps use case, where experiments reveal behavioral deviations overlooked by conventional metrics, demonstrating its effectiveness in capturing runtime uncertainties.