A comprehensive multi-omic analysis of healthy humans reveals two major axes of immunological variation characterized by interferon responses, one of which is coordinated with the microbiome and its metabolites and is stable over time within individuals.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-x

A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.