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DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

βœ‡Nature - Issue - nature.com science feeds
By: Laura Morcom Β· Wenlong Xia Β· Zhaoyang Xu Β· Yashika Awasthi Β· Celine Geywitz Β· Matthew O. Ellis Β· Tomas Noli Β· Amel Zulji Β· Daniel Yamamoto Β· Gemma C. Girdler Β· Li Kai Β· Keying Zhu Β· Mingming Wei Β· Xiao-Yan Tang Β· Kimberly K. Hoi Β· Julio Gonzalez-Maya Β· Greg J. Duncan Β· Adrien M. Vaquie Β· Diana Gold Diaz Β· Riki Kawaguchi Β· Erdong Liu Β· Yu Sun Β· Denny Yang Β· Gregory D. Jordan Β· I-Ling Lu Β· Staffan Holmqvist Β· Theresa Bartels Β· Katherine Ridley Β· Jennifer Ja-Yoon Choi Β· Santos J. Franco Β· Eric J. Huang Β· Ben Emery Β· Daniel Geschwind Β· Lucas Schirmer Β· Gabriel Balmus Β· Brian Popko Β· Stephen P. J. Fancy Β· David H. Rowitch

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
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