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Unraveling lung cancer complexity: Spatial omics in tumor microenvironment characterization and precision medicine

Curr Probl Cancer. 2026 Sep 7;65:101333. doi: 10.1016/j.currproblcancer.2026.101333. Online ahead of print.

ABSTRACT

Heterogeneous tumor microenvironment (TME) in lung cancer plays a crucial role in disease progression and resistance to therapy. Despite advances in single-cell and bulk omics profiling, these methods often overlook spatial context, which is vital for understanding cell-cell interactions and regional heterogeneity. In recent years, spatial omics technologies-including spatial genomics, transcriptomics, proteomics, and metabolomics-have revolutionized the ability to map molecular landscapes while maintaining tissue architecture. These advancements have become essential components of next-generation lung cancer management. By providing unprecedented resolution in characterizing the lung cancer TME, spatial omics could reveal prognostic and predictive biomarkers and identify new therapeutic vulnerabilities. This review will provide the first critical evaluation of spatial multi-omics approaches for lung cancer prognosis. It will also assess various integration strategies for multi-omics data to explore the clinical translational potential of these tools for therapy selection and patient stratification. Therefore, a deeper understanding of spatial omics technologies and their application in lung cancer can significantly improve precision diagnostics and therapeutic decision-making.

PMID:42705130 | DOI:10.1016/j.currproblcancer.2026.101333

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PHMForge: A Scenario-Driven Agentic Benchmark for Industrial Asset Lifecycle Maintenance

arXiv:2604.01532v1 Announce Type: new Abstract: Large language model (LLM) agents are increasingly deployed for complex tool-orchestration tasks, yet existing benchmarks fail to capture the rigorous demands of industrial domains where incorrect decisions carry significant safety and financial consequences. To address this critical gap, we introduce PHMForge, the first comprehensive benchmark specifically designed to evaluate LLM agents on Prognostics and Health Management (PHM) tasks through realistic interactions with domain-specific MCP servers. Our benchmark encompasses 75 expert-curated scenarios spanning 7 industrial asset classes (turbofan engines, bearings, electric motors, gearboxes, aero-engines) across 5 core task categories: Remaining Useful Life (RUL) Prediction, Fault Classification, Engine Health Analysis, Cost-Benefit Analysis, and Safety/Policy Evaluation. To enable rigorous evaluation, we construct 65 specialized tools across two MCP servers and implement execution-based evaluators with task-commensurate metrics: MAE/RMSE for regression, F1-score for classification, and categorical matching for health assessments. Through extensive evaluation of leading frameworks (ReAct, Cursor Agent, Claude Code) paired with frontier LLMs (Claude Sonnet 4.0, GPT-4o, Granite-3.0-8B), we find that even top-performing configurations achieve only 68\% task completion, with systematic failures in tool orchestration (23\% incorrect sequencing), multi-asset reasoning (14.9 percentage point degradation), and cross-equipment generalization (42.7\% on held-out datasets). We open-source our complete benchmark, including scenario specifications, ground truth templates, tool implementations, and evaluation scripts, to catalyze research in agentic industrial AI.
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