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DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

βœ‡Nature - Issue - nature.com science feeds
By: Laura Morcom Β· Wenlong Xia Β· Zhaoyang Xu Β· Yashika Awasthi Β· Celine Geywitz Β· Matthew O. Ellis Β· Tomas Noli Β· Amel Zulji Β· Daniel Yamamoto Β· Gemma C. Girdler Β· Li Kai Β· Keying Zhu Β· Mingming Wei Β· Xiao-Yan Tang Β· Kimberly K. Hoi Β· Julio Gonzalez-Maya Β· Greg J. Duncan Β· Adrien M. Vaquie Β· Diana Gold Diaz Β· Riki Kawaguchi Β· Erdong Liu Β· Yu Sun Β· Denny Yang Β· Gregory D. Jordan Β· I-Ling Lu Β· Staffan Holmqvist Β· Theresa Bartels Β· Katherine Ridley Β· Jennifer Ja-Yoon Choi Β· Santos J. Franco Β· Eric J. Huang Β· Ben Emery Β· Daniel Geschwind Β· Lucas Schirmer Β· Gabriel Balmus Β· Brian Popko Β· Stephen P. J. Fancy Β· David H. Rowitch

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair

βœ‡Nature - Issue - nature.com science feeds
By: Wenlong Xia Β· Laura Morcom Β· Zhaoyang Xu Β· I-Ling Lu Β· Qing Wang Β· Kimberly K. Hoi Β· Mingming Wei Β· Keying Zhu Β· Gregory Jordan Β· Xiao-Yan Tang Β· Julio Gonzalez-Maya Β· Vanesa S. Mattera Β· Sophia M. Panigrahi Β· Riki Kawaguchi Β· Ben Emery Β· Santos J. Franco Β· Daniel H. Geschwind Β· Brian Popko Β· David H. Rowitch Β· Stephen P. J. Fancy

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
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