He and colleagues developed a transient, non-gene-editing platform for off-the-shelf allogeneic TCR-T therapy. By conferring tacrolimus resistance characteristics to IL-2/4/7 expanded TCR-T cells that display reduced alloreactivity, He et al. provided a proof-of-concept for an allogeneic TCR-T therapy approach that addresses both manufacturability, and unwanted graft and host alloreactivity concerns.

arXiv:2609.10293v1 Announce Type: cross Abstract: In high-stakes domains such as legal practice, a language-model answer is only useful to the extent that a reader can verify each claim against the source the system cites. Current grounded-generation pipelines score the answer as a whole, so a correct conclusion can rest on fabricated or loosely matched citations and still score well. Closing this gap requires both a system built for per-claim verification and an evaluation that measures it. We introduce GANDR (Grounded ANswer DRafter), a two-agent system in which a Drafter writes an answer in a structured legal-reasoning format and a separate Critic, with the same view as a human verifier, audits each claim against its cited source and emits a per-claim audit trace on every round. We pair it with a strict correctness criterion requiring every citation to resolve to a passage the retriever returned. On a 185-item legal benchmark where all six systems share one backbone, one retrieval surface, and one citation instruction, GANDR ranks first on every primary metric, reaching 70.8% strict accuracy and leading the strongest baseline by 11.3 points (p

arXiv:2609.04355v2 Announce Type: replace-cross Abstract: Pretrained vision-language-action (VLA) models enable broad manipulation but remain unreliable in tasks demanding precision and repeatability. Applying real-world online reinforcement learning (RL) to VLA post-training enables autonomous trial-and-error improvement beyond demonstrations alone, but exposes two bottlenecks: 1) unreliable value signals can induce policy drift; 2) large-VLA overhead constrains throughput and sample efficiency. To address these challenges, we present VLA-Precision, an efficient real-world online RL framework featuring the Asymmetric Co-Bootstrapping (ACoB) algorithm and the ACoB-Stream architecture. Specifically, ACoB establishes asymmetric co-bootstrapping across timescales: early intervention-guided behavioral learning rapidly improves policy performance while enhancing online experience quality. As autonomous experience accumulates, global return propagation and local preference ranking progressively calibrate value estimates, yielding relative action advantages for reference-regularized policy improvement while suppressing drift. To enable ACoB on large VLAs, we develop ACoB-Stream, a closed-loop experience--policy architecture that establishes invariant-state decoupling and on-demand streaming as design principles, delivering up to 10.9$\times$ improvements in throughput and computational efficiency. Extensive evaluations on nine high-precision chemistry tasks across four categories and four robot embodiments show that VLA-Precision achieves 98.3\% mean success rate in 45.8 min/task, with 27.6 s episodes running at 1.2$\times$ and 1.8$\times$ the speeds of VLA and RL baselines. Resources are available at https://vla-precision.github.io.

arXiv:2509.16931v3 Announce Type: replace-cross Abstract: The pre-ranking stage in industrial recommendation systems faces a fundamental conflict between efficiency and effectiveness. While powerful models like Target Attention (TA) excel at capturing complex feature interactions in the ranking stage, their high computational cost makes them infeasible for pre-ranking, which often relies on simplistic vector-product models. This disparity creates a significant performance bottleneck for the entire system. To bridge this gap, we propose TARQ, a novel pre-ranking framework. Inspired by generative models, TARQ's key innovation is to equip pre-ranking with an architecture approximate to TA by Residual Quantization. This allows us to bring the modeling power of TA into the latency-critical pre-ranking stage for the first time, establishing a new state-of-the-art trade-off between accuracy and efficiency. Extensive offline experiments and large-scale online A/B tests at Taobao demonstrate TARQ's significant improvements in ranking performance. Consequently, our model has been fully deployed in production, serving tens of millions of daily active users and yielding substantial business improvements. The code and data are available at https://github.com/zyody/tarq_sigir2026.

Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10482-y

Autonomous closed-loop framework for reproducible perovskite solar cells

Nature Biotechnology, Published online: 01 April 2026; doi:10.1038/s41587-026-03051-1

ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.

arXiv:2510.00415v3 Announce Type: replace Abstract: Recent advances in large language models (LLMs) and agent system designs have empowered agents with unprecedented levels of capability. However, existing agent benchmarks are showing a trend of rapid ceiling-hitting by newly developed agents, making it difficult to meet the demands for evaluating agent abilities. To address this problem, we propose the Trajectory-based Validated-by-Reproducing Agent-benchmark Complexity Evolution (TRACE) framework. This framework takes an original task from an existing benchmark and encourages agents to freely explore and evolve it into a new task with higher difficulty while recording validatable agent trajectories. The framework proceeds in three stages: (1) evolutionary proposal mining, which provides task evolution proposals through preliminary exploration and divergent thinking; (2) problem formation and free exploration, where proposals are conceptualized into feasible problem candidates and the agents then explore them freely while recording their execution trajectories; and (3) multi-level validation, which ensures that the evolved tasks are accompanied by validatable and reproducible trajectories. Experiments on the GAIA benchmark demonstrate that the TRACE framework consistently enhances task complexity while improving the reliability of correctness through validatable execution trajectories. In addition, our framework can successfully adapt to and improve reasoning datasets represented by AIME-2024. This work marks a paradigm shift from static, manually curated benchmarks to dynamic, self-evolving evaluation systems, providing a sustainable and challenging runway for agent development

arXiv:2509.26354v2 Announce Type: replace Abstract: Advances in Large Language Models (LLMs) have enabled a new class of self-evolving agents that autonomously improve through interaction with the environment, demonstrating strong capabilities. However, self-evolution also introduces novel risks overlooked by current safety research. In this work, we study the case where an agent's self-evolution deviates in unintended ways, leading to undesirable or even harmful outcomes. We refer to this as Misevolution. To provide a systematic investigation, we evaluate misevolution along four key evolutionary pathways: model, memory, tool, and workflow. Our empirical findings reveal that misevolution is a widespread risk, affecting agents built even on top-tier LLMs (e.g., Gemini-2.5-Pro). Different emergent risks are observed in the self-evolutionary process, such as the degradation of safety alignment after memory accumulation, or the unintended introduction of vulnerabilities in tool creation and reuse. To our knowledge, this is the first study to systematically conceptualize misevolution and provide empirical evidence of its occurrence, highlighting an urgent need for new safety paradigms for self-evolving agents. Finally, we discuss potential mitigation strategies to inspire further research on building safer and more trustworthy self-evolving agents. Our code and data are available at https://github.com/ShaoShuai0605/Misevolution . Warning: this paper includes examples that may be offensive or harmful in nature.

arXiv:2601.20538v2 Announce Type: replace-cross Abstract: Large language model-powered multi-agent systems have emerged as powerful tools for simulating complex human-like systems. The interactions within these systems often lead to extreme events whose origins remain obscured by the black box of emergence. Interpreting these events is critical for system safety. This paper proposes the first framework for explaining emergent extreme events in multi-agent systems, aiming to answer three fundamental questions: When does the event originate? Who drives it? And what behaviors contribute to it? Specifically, we adapt the Shapley value to faithfully attribute the occurrence of extreme events to each action taken by agents at different time steps, i.e., assigning an attribution score to the action to measure its influence on the event. We then aggregate the attribution scores along the dimensions of time, agent, and behavior to quantify the risk contribution of each dimension. Finally, we design a set of metrics based on these contribution scores to characterize the features of extreme events. Experiments across diverse multi-agent system scenarios (economic, financial, and social) demonstrate the effectiveness of our framework and provide general insights into the emergence of extreme phenomena.