arXiv:2503.12797v3 Announce Type: replace-cross Abstract: Knowledge-Intensive Visual Grounding (KVG) requires models to localize objects using fine-grained, domain-specific entity names rather than generic referring expressions. Although Multimodal Large Language Models (MLLMs) possess rich entity knowledge and strong generic grounding capabilities, they often fail to effectively utilize such knowledge when grounding specialized concepts, revealing a knowledge-grounding gap between internal knowledge and grounding predictions. To address this challenge, we propose a knowledge-aware training paradigm for KVG. Our approach first constructs knowledge-guided reasoning data to encourage models to activate domain-relevant entity knowledge during grounding, and then introduces KARL, a Knowledge-Aware Reinforcement Learning framework that adaptively modulates reward signals according to the model's estimated knowledge mastery of different entities. To facilitate systematic evaluation, we introduce KVG-Bench, a benchmark spanning 10 domains with 1.3K curated test cases covering 531 images and 882 entities. Extensive experiments show that our approach consistently outperforms a wide range of baseline models and achieves substantially stronger cross-domain generalization on unseen categories. The data, codes, and models are released at https://github.com/thunlp/KARL.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02424-9

Evaluating eRAMP telecare for diabetes in outpatient clinics: a hybrid effectiveness-implementation study

Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6

TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation

arXiv:2603.12793v1 Announce Type: cross Abstract: A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly optimize within a shared feature space. In this work, we present Cheers, a unified multimodal model that decouples patch-level details from semantic representations, thereby stabilizing semantics for multimodal understanding and improving fidelity for image generation via gated detail residuals. Cheers includes three key components: (i) a unified vision tokenizer that encodes and compresses image latent states into semantic tokens for efficient LLM conditioning, (ii) an LLM-based Transformer that unifies autoregressive decoding for text generation and diffusion decoding for image generation, and (iii) a cascaded flow matching head that decodes visual semantics first and then injects semantically gated detail residuals from the vision tokenizer to refine high-frequency content. Experiments on popular benchmarks demonstrate that Cheers matches or surpasses advanced UMMs in both visual understanding and generation. Cheers also achieves 4x token compression, enabling more efficient high-resolution image encoding and generation. Notably, Cheers outperforms the Tar-1.5B on the popular benchmarks GenEval and MMBench, while requiring only 20% of the training cost, indicating effective and efficient (i.e., 4x token compression) unified multimodal modeling. We will release all code and data for future research.

Nature, Published online: 16 March 2026; doi:10.1038/s41586-026-10372-3

Direct conversion from alkenes to alkynes

arXiv:2603.06739v1 Announce Type: cross Abstract: Autonomous agents are increasingly expected to support scientific research, and recent benchmarks report progress in code repair and autonomous experimentation. However, these evaluations typically assume a pre-configured execution environment, which requires resolving complex software dependencies, aligning hardware and framework versions, and configuring distributed execution, yet this capability remains largely unbenchmarked. We introduce ResearchEnvBench, a benchmark for environment synthesis in research code execution. Given a research repository, documentation, and a target execution setting, agents must construct an environment that successfully executes at runtime. Evaluations on diverse research repositories reveal a substantial gap in current SOTA agents, with failures dominated by incomplete dependency resolution and brittle version coupling. ResearchEnvBench provides a realistic testbed for advancing autonomous agents toward reproducible scientific research.