Agarwal et al. introduce MitoSpace, a self-supervised model trained on 4D lattice light-sheet microscopy data. The model resolves drug-induced mitochondrial phenotypes without labels, predicts membrane potential from morphology and dynamics, generalizes to unseen perturbations and lung organoids, and shows that representation quality improves progressively from 2D to 4D.

arXiv:2605.26001v1 Announce Type: cross Abstract: Evaluating generative AI (GenAI) systems is challenging because many targets of evaluation are broad, contested concepts, such as "reasoning," "fairness," or "creativity." When these concepts are left underspecified, it becomes unclear what should be measured or how evaluation results should be interpreted. This problem reflects a missing step: systematization, that is, moving from a broad background concept to an explicit, structured account of the concept in measurable terms. To help address the fact that systematization is cognitively demanding and resource-intensive, we investigate whether AI assistance can support this process. To enable AI-assisted systematization and assess its quality, we introduce a structured representation of a systematized concept, a concept spec, and a validation worksheet. We then develop two AI-assisted systematizers: a direct, zero-shot approach and a multi-agent approach that more closely mirrors manual systematization approaches from existing literature. We use these systematizers to produce concept specs for two concepts -- hate-based rhetoric and digital empathy -- and evaluate resulting concept specs on content validity and information recoverability.