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Targeting EZH2 and EGFR Therapeutic Vulnerabilities of TNBC with a Single Chemical Entity Confers Preclinical Treatment Advantage

Utilizing medicinal chemistry approach, Datta and colleagues demonstrate that EZH2-EGFR dual targeting halts protein translation in TNBC and inhibits tumor growth and metastasis in preclinical animal models.
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Concurrent upregulation of autophagic flux and induction of the SQSTM1/p62-VCAM-1 axis deter radiosensitivity of triple-negative breast cancer cells

Cell Death Discovery, Published online: 01 September 2026; doi:10.1038/s41420-026-03316-3

Concurrent upregulation of autophagic flux and induction of the SQSTM1/p62-VCAM-1 axis deter radiosensitivity of triple-negative breast cancer cells
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