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Integrative Multi-Omics Analysis Identifies FTO as a Genetic and Epigenetic Link Between Metabolic Susceptibility and Staphylococcus aureus-Induced Airway Remodeling in Chronic Rhinosinusitis

Chem Biol Drug Des. 2026 Apr;107(4):e70297. doi: 10.1111/cbdd.70297.

ABSTRACT

This study identifies fat mass and obesity-associated protein (FTO) as a pivotal link between metabolic predisposition and pathogenesis associated with Staphylococcus aureus in chronic rhinosinusitis (CRS). These findings were established through the application of an integrative multi-omics framework. We demonstrate that S. aureus upregulates FTO, which functions as an m6A demethylase to stabilize the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1). This molecular axis suppresses GSK-3Ξ² and promotes Ξ²-catenin nuclear translocation, thereby driving epithelial-mesenchymal transition (EMT) and pathological mucosal remodeling. By mapping the FTO-MALAT1-GSK-3Ξ²/Ξ²-catenin signaling network, this research elucidates how metabolic susceptibility facilitates infection-triggered epithelial reprogramming. These findings establish FTO as a promising biomarker and potential therapeutic target, providing a systemic foundation for personalized CRS treatment strategies.

PMID:41973807 | DOI:10.1111/cbdd.70297

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Design Principles for the Construction of a Benchmark Evaluating Security Operation Capabilities of Multi-agent AI Systems

arXiv:2603.28998v1 Announce Type: cross Abstract: As Large Language Models (LLMs) and multi-agent AI systems are demonstrating increasing potential in cybersecurity operations, organizations, policymakers, model providers, and researchers in the AI and cybersecurity communities are interested in quantifying the capabilities of such AI systems to achieve more autonomous SOCs (security operation centers) and reduce manual effort. In particular, the AI and cybersecurity communities have recently developed several benchmarks for evaluating the red team capabilities of multi-agent AI systems. However, because the operations in SOCs are dominated by blue team operations, the capabilities of AI systems & agents to achieve more autonomous SOCs cannot be evaluated without a benchmark focused on blue team operations. To our best knowledge, no systematic benchmark for evaluating coordinated multi-task blue team AI has been proposed in the literature. Existing blue team benchmarks focus on a particular task. The goal of this work is to develop a set of design principles for the construction of a benchmark, which is denoted as SOC-bench, to evaluate the blue team capabilities of AI. Following these design principles, we have developed a conceptual design of SOC-bench, which consists of a family of five blue team tasks in the context of large-scale ransomware attack incident response.
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