Nature Cancer, Published online: 01 September 2026; doi:10.1038/s43018-026-01220-4

Chen et al. have developed SlideChat, a multimodal generative artificial intelligence assistant, which they benchmark on 27 pathology tasks across 33 cancer types. Expert pathologists rated the assistant as clinically relevant and accurate.

arXiv:2604.04078v1 Announce Type: cross Abstract: Cardiac magnetic resonance (CMR) is a cornerstone for diagnosing cardiovascular disease. However, it remains underutilized due to complex, time-consuming interpretation across multi-sequences, phases, quantitative measures that heavily reliant on specialized expertise. Here, we present BAAI Cardiac Agent, a multimodal intelligent system designed for end-to-end CMR interpretation. The agent integrates specialized cardiac expert models to perform automated segmentation of cardiac structures, functional quantification, tissue characterization and disease diagnosis, and generates structured clinical reports within a unified workflow. Evaluated on CMR datasets from two hospitals (2413 patients) spanning 7-types of major cardiovascular diseases, the agent achieved an area under the receiver-operating-characteristic curve exceeding 0.93 internally and 0.81 externally. In the task of estimating left ventricular function indices, the results generated by this system for core parameters such as ejection fraction, stroke volume, and left ventricular mass are highly consistent with clinical reports, with Pearson correlation coefficients all exceeding 0.90. The agent outperformed state-of-the-art models in segmentation and diagnostic tasks, and generated clinical reports showing high concordance with expert radiologists (six readers across three experience levels). By dynamically orchestrating expert models for coordinated multimodal analysis, this agent framework enables accurate, efficient CMR interpretation and highlights its potentials for complex clinical imaging workflows. Code is available at https://github.com/plantain-herb/Cardiac-Agent.

arXiv:2603.06589v1 Announce Type: cross Abstract: Model calibration and debiasing are fundamental to the reliability and fairness of large scale recommendation systems. We introduce the Isotonic Layer, a novel, differentiable framework that integrates piecewise linear fitting directly into neural architectures. By partitioning the feature space into discrete segments and optimizing non negative slopes via a constrained dot product mechanism, we enforce a global monotonic inductive bias. This ensures model outputs remain logically consistent with critical features such as latent relevance, recency, or quality scores. We further generalize this architecture by parameterizing segment wise slopes as learnable embeddings. This enables the model to adaptively capture context specific distortions, such as position based CTR bias through specialized isotonic profiles. Our approach utilizes a dual task formulation that decouples the recommendation objective into latent relevance estimation and bias aware calibration. A major contribution of this work is the ability to perform highly granular, customized calibration for arbitrary combinations of context features, a level of control difficult to achieve with traditional non parametric methods. We also extend this to Multi Task Learning environments with dedicated embeddings for distinct objectives. Extensive empirical evaluations on real world datasets and production AB tests demonstrate that the Isotonic Layer effectively mitigates systematic bias and enhances calibration fidelity, significantly outperforming production baselines in both predictive accuracy and ranking consistency.