Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03992-6

A positive feedback loop between YTHDC1 and EP300 drives multiple myeloma tumorigenesis

arXiv:2604.03309v1 Announce Type: cross Abstract: 3D Gaussian Splatting (3DGS) has emerged as a real-time, differentiable representation for neural scene understanding. However, existing 3DGS-based methods struggle to represent hierarchical 3D semantic structures and capture whole-part relationships in complex scenes. Moreover, dense pairwise comparisons and inconsistent hierarchical labels from 2D priors hinder feature learning, resulting in suboptimal segmentation. To address these limitations, we introduce TreeGaussian, a tree-guided cascaded contrastive learning framework that explicitly models hierarchical semantic relationships and reduces redundancy in contrastive supervision. By constructing a multi-level object tree, TreeGaussian enables structured learning across object-part hierarchies. In addition, we propose a two-stage cascaded contrastive learning strategy that progressively refines feature representations from global to local, mitigating saturation and stabilizing training. A Consistent Segmentation Detection (CSD) mechanism and a graph-based denoising module are further introduced to align segmentation modes across views while suppressing unstable Gaussian points, enhancing segmentation consistency and quality. Extensive experiments, including open-vocabulary 3D object selection, 3D point cloud understanding, and ablation studies, demonstrate the effectiveness and robustness of our approach.

arXiv:2603.07472v1 Announce Type: cross Abstract: In this study, we present a conditional diffusion-transformer framework for generating ensembles of three-dimensional Escherichia coli genome conformations guided by Hi-C contact maps. Instead of producing a single deterministic structure, we formulate genome reconstruction as a conditional generative modeling problem that samples heterogeneous conformations whose ensemble-averaged contacts are consistent with the input Hi-C data. A synthetic dataset is constructed using coarse-grained molecular dynamics simulations to generate chromatin ensembles and corresponding Hi-C maps under circular topology. Our models operate in a latent diffusion setting with a variational autoencoder that preserves per-bin alignment and supports replication-aware representations. Hi-C information is injected through a transformer-based encoder and cross-attention, enforcing a physically interpretable one-way constraint from Hi-C to structure. The model is trained using a flow-matching objective for stable optimization. On held-out ensembles, generated structures reproduce the input Hi-C distance-decay and structural correlation metrics while maintaining substantial conformational diversity, demonstrating the effectiveness of diffusion-based generative modeling for ensemble-level 3D genome reconstruction.