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Predicting genome-wide functional constraints with GPN-Star

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species.
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Mapping <i>cis</i>-regulatory mutations at scale in sorghum enables modulation of gene expression

Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
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