Oncogene, Published online: 28 September 2026; doi:10.1038/s41388-026-03996-2

SPTLC2-driven sphingolipid reprogramming of neutrophils impairs anti-tumour immunity and drives liver cancer progression

Nature Nanotechnology, Published online: 15 September 2026; doi:10.1038/s41565-026-02276-0

Monolithic 3D integration of oxide semiconductor devices on a 200-mm wafer is demonstrated, enabling vertically interconnected logic and memory and supporting the design of an energy-efficient AI accelerator.

Nature Medicine, Published online: 15 September 2026; doi:10.1038/s41591-026-04609-x

An autonomous clinical AI agent enhances decision-making through on-premise deployment and reliability metrics, achieving high diagnostic accuracy and selective autonomy.

arXiv:2609.12136v1 Announce Type: cross Abstract: Prequential adaptation of frozen tabular foundation models under temporal drift, with each label revealed only after prediction, helps some deployments and harms others, yet current practice does not predict which. We study the sources and limits of these gains. A diagnostic anatomy attributes gains to four recurring mechanisms under a streaming protocol that removes three optimistic biases and quantifies a fourth. Within an agnostic total-variation drift class, the target conditional is only partially identified: its identified-set diameter, the \emph{wall}, is irreducible from unlabeled data uniformly in sample size. A second, orthogonal $L^2$ projection wall quantifies what the frozen representation cannot express. Two canonical mechanism priors collapse the first wall. Under stated nuisance-rate conditions, the wall can be estimated from labeled historical windows at a $\sqrt N$ rate above the margin threshold $\gamma^\star=d_0/(2\alpha_s)$. At $\gamma=0$, the conditional lower-bound program depends on an open affinity estimate; the positive-margin lower branch also remains open. Semi-synthetic data illustrate the finite-sample mechanism with calibrated exponents. Stream-level proxies on eight industrial streams fall on the difficult side under a stated roughness bound, while the equality case $\gamma=\gamma^\star$ remains unresolved.

arXiv:2601.10696v2 Announce Type: replace Abstract: Generative AI (GenAI) is increasingly adopted in design education, yet evaluating its educational value through final outcomes provides an incomplete picture. This study compares two ecologically plausible workflows in an architectural conceptual design task: GenAI-assisted image generation and ArchDaily-based precedent search. The comparison concerns complete workflows rather than the isolated contributions. Thirty-six students completed a two-phase design task, first designing independently and then revising with their assigned workflow. Eight judges rated design performance, while participants reported task-specific and general creative self-efficacy and cognitive load after each phase. Difference-in-differences analyses showed no significant overall differences between the GenAI and precedent-search workflows in design performance, cognitive workload, or task-specific creative self-efficacy. Beyond these null overall effects, three patterns were observed. General creative self-efficacy showed a significant relative decline under the GenAI workflow. A subgroup analysis suggested higher revision-phase performance among novice students using GenAI than among those using precedent search (F (1,32) = 4.303, p = 0.046). However, this exploratory interaction should be interpreted cautiously due to low rating reliability, small subgroup cells, and imprecise estimation. Third, exploratory prompt analyses suggested that iterative, task-specific prompting strategies (CD3, CD6) were associated with cognitive load reductions at the uncorrected level, but neither association survived multiple-comparison correction. Overall, the GenAI workflow did not produce uniform gains. Its educational value may depend on pedagogical framing, learner characteristics, and human-AI interaction structure, underscoring the need to preserve creative agency and develop prompt literacy.

arXiv:2504.04903v3 Announce Type: replace-cross Abstract: We present Lunima-OmniLV (abbreviated as OmniLV), a universal multimodal multi-task framework for low-level vision that addresses over 100 sub-tasks across four major categories: image restoration, image enhancement, weak-semantic dense prediction, and stylization. OmniLV leverages both textual and visual prompts to offer flexible and user-friendly interactions. Built on Diffusion Transformer (DiT)-based generative priors, our framework supports arbitrary resolutions -- achieving optimal performance at 1K resolution -- while preserving fine-grained details and high fidelity. Through extensive experiments, we demonstrate that separately encoding text and visual instructions, combined with co-training using shallow feature control, is essential to mitigate task ambiguity and enhance multi-task generalization. Our findings also reveal that integrating high-level generative tasks into low-level vision models can compromise detail-sensitive restoration. These insights pave the way for more robust and generalizable low-level vision systems.

arXiv:2608.18234v3 Announce Type: replace-cross Abstract: Whole-body motion tracking policies turn a humanoid into a robust control interface: the teleoperator---or an upstream model---only supplies a coarse movement intent, while the low-level policy keeps the robot balanced and physically feasible. Existing trackers deliver this interface only on flat ground: trained in empty scenes, they never learn how contact with terrain and objects reshapes their dynamics, and they attempt to teach the policy to balance under any command by continually enlarging the reference-motion corpus, which stops working once feasible behaviors become environment-dependent. We present GigaBrain-WBC-0.5, the first Behavior World Model (BWM) for humanoid whole-body control. Rather than a purely reactive tracker, we train a causal Transformer to jointly predict its next action, next state, and the distribution over its next latent behavior command, so the network that acts also models how the environment shapes what it can do next. An automatic terrain-annotation pipeline recovers full 3D contact geometry from retargeted motion, enabling terrain annotation at the scale of existing motion datasets. The predicted distribution is reused at deployment to detect implausible commands online and retract them onto learned behaviors, so the robot attempts tasks in a "best-effort" manner. The result is a unified policy that takes real-time command, interacts with environment, and stays robust to implausible commands, falls, and disturbances. GigaBrain-WBC-0.5 achieves the highest success rate across all four regimes among three large-scale tracker baselines: 81.3% on terrain interaction (4.3x the strongest baseline), 83.1% under implausible commands, and 99.3% fall recovery (16.8x the strongest baseline). Hardware trials show robust interaction under missing supports and disturbances; the Unitree G1 checkpoint transfers to the Maker L01 robot with simple fine-tuning.

Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03976-6

Tumor-derived CTHRC1 mediates ITGB3-dependent osteoclast differentiation to promote prostate cancer bone metastasis

Background: Patients with breast cancer during postoperative chemotherapy intervals commonly experience psychological distress and reduced resilience while recovering at home. Digital mindfulness interventions may provide accessible psychological support during this vulnerable period; however, evidence regarding tailored interventions for postoperative patients with breast cancer during chemotherapy intervals remains limited. Objective: This study aimed to examine the effectiveness of a digital intervention on psychological resilience in postoperative patients with breast cancer during chemotherapy intervals. Methods: A quasi-experimental study with repeated measures was conducted from October 2021 to June 2022. A total of 80 eligible participants were recruited from the Department of Breast Surgery at a tertiary hospital in Zhejiang Province, China, and 71 completed the study. The control group received routine discharge instructions and nursing follow-ups, whereas the intervention group additionally received an 8-week digital psychological resilience intervention. Outcomes were assessed at baseline (T0), 3 months post intervention (T1), and 6 months post intervention (T2). The measures included the Connor-Davidson Resilience Scale (CD-RISC), Hospital Anxiety and Depression Scale (HADS), Social Support Rating Scale (SSRS), Breast Cancer Survivor Self-Efficacy Scale (BCSSS), and Functional Assessment of Cancer Therapy-Breast (FACT-B). Independent-samples tests, chi-square tests, and repeated-measures ANOVA were performed using SPSS (version 26.0; IBM Corp). Results: No statistically significant baseline differences were observed between the two groups in the outcome measures. At T1, the intervention group had higher CD-RISC scores than the control group (mean 67.58, SD 11.41 vs mean 62.09, SD 10.18; =.036) and higher BCSSS scores (mean 42.36, SD 3.59 vs mean 39.23, SD 4.90; =.003). However, these between-group differences were no longer statistically significant at T2 (>.05). Significant time effects and group×time interaction effects were observed for both psychological resilience and self-efficacy (.05), although both scales showed significant time effects (

Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-x

Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m⁶A modification

Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne adeno-associated virus (AAV) Rep/Cap genes during recombinant AAV (rAAV) production. This new approach not only enables a 10- to 20-fold plasmid reduction to significantly lower manufacturing costs but also substantially enhances rAAV potency, titer, and purity.

This study developed a multi-layer inducible RNA switch that achieves transient expression of gene-delivery vectors in hepatic and non-hepatic tissues. As an exemplary application, this RNA switch triggers pulsive expression of gene editors that reduces the off-target effects and immunotoxicity of gene editing.

In the infection courses of different SARS-CoV-2 variants, disease outcomes and signatures were delineated by physiological changes, viral load, pathology, and pulmonary transcriptome analysis. This multi-dimensional landscape of disease outcomes and underlying mechanisms might provide important clues for immunotherapy of SARS-CoV-2 infection and pneumonia caused by other respiratory viruses.

arXiv:2609.09925v1 Announce Type: new Abstract: Modern vision-language-action (VLA) policies predict a whole chunk of actions: one to two seconds of coordinated motion emitted in a single forward pass. Yet an action chunk is essentially a short multivariate trajectory, but inside these models it is a sequence of generic per-timestep hidden tokens decoded by a linear head. This under-serves two motion structures. First, frequency: a chunk superimposes a smooth global trend and fine corrective motion across time scales, and a single token entangles them. Second, cross-phase geometry: motions of different phases (reach, contact, grasp adjustment, settling) unfold along very different, near-orthogonal directions in representation space, yet are tightly related for the task and arise across the time axis. Dot-product attention scores alignment by an inner product, so it favors aligned tokens and is least sensitive near orthogonality, leaving such relationships for the network to recover through a detour. We introduce Time-Frequency Geometric Cross-Attention (TFGCA), a drop-in module repairing both blind spots. TFGCA uses a per-dimension learnable stationary wavelet transform to decompose the action chunk into time-frequency tokens, and each time token retrieves information from them via a cross-attention that fuses the dot product (similarity) with the wedge-product magnitude (sensitive to near-orthogonality) through a learnable weight. A zero-initialized residual reproduces the base behavior at initialization, so it can be dropped onto a pretrained VLA and fine-tuned jointly. Relative to the same-source base, TFGCA improves in-distribution LIBERO by +1.5 on average, the OOD LIBERO-Plus by +6.3, the randomized average under RoboTwin domain randomization by +28.5, and the overall success rate on three real-robot AgiBot A2 tasks by +11.67 points, with larger gains out of distribution.

arXiv:2609.09212v1 Announce Type: cross Abstract: This paper presents an end-to-end evaluation framework for image-triggered command injection against computer-use agents (CUAs). The goal is to test whether a local visual patch can induce verifiable environmental consequences along the full chain of screenshot input, VLM generation, action parsing, and environment execution. We train and deploy patches on author-controlled GitHub Pages pages and a locally deployed CSDN clone, and evaluate them in real environments across five open-source or publicly available GUI-agent or vision-language-model (VLM) backends. Our experiment aggregates 600 instance-level online cases, with T-ASR, TAPR, and E2E-ASR reaching 84.5%, 47.0%, and 20.3%, respectively. Trajectory analysis further shows that in some successful cases the agent first executes a malicious terminal command and then continues the original benign task. These results indicate that optimized local visual signals can affect not only VLM outputs but also propagate through the execution pipeline of open CUAs and create real environmental risk.

arXiv:2609.09213v1 Announce Type: cross Abstract: We study how physical-state inputs affect a 0.8B hybrid language model adapted for manipulation with 6.2M trainable parameters. Six conditions are trained on three LIBERO-Spatial tasks and evaluated over three seeds and 540 held-out rollouts. Conditioning recurrent decay gates on geometric increments yields 28.9% success, compared with 36.7% when those increments are shuffled during training and 24.4% without explicit object/goal geometry. Both geometry policies receive correct inputs at evaluation. A token adapter using the same increments scores 27.8%; differences vary across seeds and remain inconclusive. Token-clock conditioning scores 11.1%, including one seed that fails to converge. In separate robustness tests, a state-only relative-coordinate policy retains 7/10 success under frame relabeling, whereas all four tested visual policies fall to at most 3/20 after a 5 cm object displacement. These results show no reliable advantage from training-time geometric alignment under this recipe and illustrate the gap between coordinate invariance and physical-layout generalization. Episode records, seed-level analyses, and figure-generation code accompany the paper.

arXiv:2609.04298v2 Announce Type: replace Abstract: Evaluating agents on the growing number of agentic benchmarks is challenging because they often require complex environments and agent integrations. We introduce Harbor Adapters, a unified evaluation infrastructure for agentic benchmarks. Our work makes three contributions. First, we develop benchmark adapters that port more than 80 benchmarks to evaluate arbitrary agents, and validate them through rigorous code review and parity experiments. Second, we conduct a large-scale evaluation of 8 models spanning capability tiers across 54 benchmarks; every model is run with Terminus-2 and with one of 3 native harnesses. This enables a broader analysis of agent capabilities and failure modes than was previously possible. Third, we introduce Harbor-Index, a curated set of 82 difficult, diverse, and high-quality tasks spanning 29 benchmarks, refined from the adapted suite through difficulty filtering, AI and human audit, and an audit-and-fix loop. Harbor-Index preserves the challenge and breadth of large-scale agentic evaluations while being affordable to run; no evaluated model-harness configuration exceeds 30% pass rate, and the strongest (GPT-5.5 with Codex) reaches 28.0%. We release the adapters, evaluation results, in-depth analysis, and Harbor-Index as open-source artifacts to support more reliable and comprehensive evaluation of language-model agents.

arXiv:2606.08653v2 Announce Type: replace-cross Abstract: Action-supervised fine-tuning of vision-language-action (VLA) policies fits demonstrations effectively but constrains only the directions that change predicted actions, leaving visual structure consistent across action-equivalent states free to collapse. We formalize this as residual visual collapse along local action fibers and propose FiberTune, a training-time objective that preserves teacher-structured visual residuals without adding inference-time overhead. FiberTune uses an online action probe to estimate action-predictive feature directions, filters them from intermediate visual-token representations, and aligns the resulting probe-filtered residuals to a frozen visual teacher while regularizing their effective rank. Under identical training conditions, FiberTune improves over task-loss-only fine-tuning in every one of six controlled simulation settings spanning two benchmarks and two architectures (pi_0.5 and OpenVLA-OFT), as well as on physical SO-101 pick-place; representative gains include +10.7 percentage points SR(5) on long-horizon CALVIN ABC-to-D and physical SO-101 task success rising from 72.7% to 78.1%. Residual diagnostics show that these gains coincide with increased probe-filtered residual teacher alignment and effective rank, consistent with the action-fiber motivation.

arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragmenting perception, reasoning, and action while offering limited generalization. Here we present LightNav-0, a compact generalist embodied navigation model that elicits the spatial intelligence of a pretrained VLM and aligns it with navigation, without task-specific prediction heads. LightNav-0 represents diverse navigation tasks through a unified token interface: dual-channel pointing expresses task-, scene-, and embodiment-agnostic spatial intent, while a residual vector-quantized action tokenizer maps this intent to precise, embodiment-specific trajectories. Together with temporally aware visual history compression, ER mid-training, supervised fine-tuning, and reinforcement learning, this formulation supports instruction following, open-vocabulary object navigation, and visual tracking within a single model. The navigation training corpus spans 2K+ scenes and 4K+ hours of embodied navigation data. LightNav-ER, the embodied-reasoning checkpoint used to initialize LightNav-0, attains the highest complete-set average across 8 embodied-reasoning benchmarks, while LightNav-0 achieves state-of-the-art monocular success rates across all 10 public navigation simulation settings. Real-world evaluations further demonstrate zero-shot generalization across robot embodiments, diverse scenes, and static and dynamic targets. These results establish compact VLMs as a unified and transferable backbone for generalist embodied navigation.