Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01780-x

A long-term flexible electrode array system stably tracks individual neurons for months, revealing intrinsic drift in visual evoked neural activity and potentiating durable cross-session and cross-animal decoding.

Cell Death Discovery, Published online: 07 September 2026; doi:10.1038/s41420-026-03299-1

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

arXiv:2604.04373v1 Announce Type: new Abstract: There is growing interest in improving LLMs without updating model parameters. One well-established direction is test-time scaling, where increased inference-time computation (e.g., longer reasoning, sampling, or search) is used to improve performance. However, for complex reasoning and agentic tasks, naively scaling test-time compute can substantially increase cost and still lead to wasted budget on suboptimal exploration. In this paper, we explore \emph{context} as a complementary scaling axis for improving LLM performance, and systematically study how to construct better inputs that guide reasoning through \emph{experience}. We show that effective context construction critically depends on \emph{decocted experience}. We present a detailed analysis of experience-augmented agents, studying how to derive context from experience, how performance scales with accumulated experience, what characterizes good context, and which data structures best support context construction. We identify \emph{decocted experience} as a key mechanism for effective context construction: extracting essence from experience, organizing it coherently, and retrieving salient information to build effective context. We validate our findings across reasoning and agentic tasks, including math reasoning, web browsing, and software engineering.

arXiv:2604.03497v1 Announce Type: cross Abstract: Deploying reinforcement learning policies trained in simulation to real autonomous vehicles remains a fundamental challenge, particularly for VLM-guided RL frameworks whose policies are typically learned with simulator-native observations and simulator-coupled action semantics that are unavailable on physical platforms. This paper presents Sim2Real-AD, a modular framework for zero-shot sim-to-real transfer of CARLA-trained VLM-guided RL policies to full-scale vehicles without any real-world RL training data. The framework decomposes the transfer problem into four components: a Geometric Observation Bridge (GOB) that converts monocular front-view images into simulator-compatible bird's-eye-view (BEV) observations, a Physics-Aware Action Mapping (PAM) that translates policy outputs into platform-agnostic physical commands, a Two-Phase Progressive Training (TPT) strategy that stabilizes adaptation by separating action-space and observation-space transfer, and a Real-time Deployment Pipeline (RDP) that integrates perception, policy inference, control conversion, and safety monitoring for closed-loop execution. Simulation experiments show that the framework preserves the relative performance ordering of representative RL algorithms across different reward paradigms and validate the contribution of each module. Zero-shot deployment on a full-scale Ford E-Transit achieves success rates of 90%, 80%, and 75% in car-following, obstacle avoidance, and stop-sign interaction scenarios, respectively. To the best of our knowledge, this study is among the first to demonstrate zero-shot closed-loop deployment of a CARLA-trained VLM-guided RL policy on a full-scale real vehicle without any real-world RL training data. The demo video and code are available at: https://zilin-huang.github.io/Sim2Real-AD-website/.

arXiv:2602.13891v1 Announce Type: cross Abstract: Recent advances in speech language models, such as GPT-4o Voice Mode and Gemini Live, have demonstrated promising speech generation capabilities. Nevertheless, the aesthetic naturalness of the synthesized audio still lags behind that of human speech. Enhancing generation quality requires a reliable evaluator of speech naturalness. However, existing naturalness evaluators typically regress raw audio to scalar scores, offering limited interpretability of the evaluation and moreover fail to generalize to speech across different taxonomies. Inspired by recent advances in generative reward modeling, we propose the Generative Speech Reward Model (GSRM), a reasoning-centric reward model tailored for speech. The GSRM is trained to decompose speech naturalness evaluation into an interpretable acoustic feature extraction stage followed by feature-grounded chain-of-thought reasoning, enabling explainable judgments. To achieve this, we curated a large-scale human feedback dataset comprising 31k expert ratings and an out-of-domain benchmark of real-world user-assistant speech interactions. Experiments show that GSRM substantially outperforms existing speech naturalness predictors, achieving model-human correlation of naturalness score prediction that approaches human inter-rater consistency. We further show how GSRM can improve the naturalness of speech LLM generations by serving as an effective verifier for online RLHF.

arXiv:2601.21654v2 Announce Type: replace Abstract: Large language models have advanced from single-turn question answering to deep research systems that iteratively decompose research questions, invoke retrieval tools, and synthesize information across multiple rounds. Evaluating such systems typically involves scoring their final research reports holistically, but this end-to-end paradigm tightly couples the language model's decision-making, workflow design, and environmental feedback, precluding decomposable analysis of individual components. We introduce ScholarGym, an evaluation environment that isolates the information-gathering stage of deep research on academic literature. Under a unified workflow, ScholarGym decomposes the research process into three explicit stages -- Query Planning, Tool Invocation, and Relevance Assessment -- and evaluates each against 2,536 expert-annotated queries over a static corpus of 570K papers with deterministic retrieval. Systematic experiments reveal that iterative query decomposition yields 2.9--3.3$\times$ F1 gains over single-query retrieval, models with extended thinking trade recall for precision, and Query Planning quality together with Relevance Assessment constitute dual bottlenecks that separate proprietary from open-source model performance.

arXiv:2504.21205v3 Announce Type: replace-cross Abstract: This paper introduces SecRepoBench, a benchmark to evaluate code agents on secure code completion in real-world repositories. SecRepoBench has 318 code completion tasks in 27 C/C++ repositories, covering 15 CWEs. We evaluate 29 standalone LLMs and 15 code agents across 3 state-of-the-art agent frameworks using our benchmark. We find that state-of-the-art LLMs struggle with generating correct and secure code completions. However, code agents significantly outperform standalone LLMs. We show that SecRepoBench is more difficult than the prior state-of-the-art benchmark. Finally, our comprehensive analysis provides insights into potential directions for enhancing the ability of code agents to write correct and secure code in real-world repositories.