Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01786-5

A nanoscale metal–organic framework (MOF)-based cancer vaccine platform enables coordinated antigen presentation and innate immune activation, resulting in tumour regression, immune memory and protection against metastasis.

arXiv:2606.10531v3 Announce Type: replace-cross Abstract: Quantization-aware training (QAT) is essential for extremely low-bit large language models (LLMs). Current QAT methods are mainly based on scalar quantization (SQ), which enables efficient optimization but suffers from severe performance degradation at 2-bit precision. On the other hand, vector quantization (VQ) provides substantially higher representational capacity, but its discrete codebook lookup prevents end-to-end training. We propose LC-QAT, a 2-bit weight-only VQ-QAT framework that represents quantized weights via a learned affine mapping over discrete vectors, which yields a high-quality PTQ initialization and enables fully differentiable end-to-end optimization without explicit codebook lookup in the training forward pass. This strong post-training initialization makes LC-QAT highly data-efficient. Experiments across diverse LLMs demonstrate that LC-QAT consistently outperforms state-of-the-art QAT methods while using only 0.1%--10% of the training data. Our results establish LC-QAT as a practical and scalable solution for extreme low-bit model deployment. Codes are publicly available at https://github.com/AI9Stars/UniSVQ.

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01782-9

A protein engineering strategy enables nitric oxide-triggered reactivation of proteins using genetically encoded caged amino acids, allowing inflammation-localized control of protein activity, viral gene delivery and biosensing in vivo.

arXiv:2602.03151v2 Announce Type: replace Abstract: Vision Language Model (VLM) typically assume complete modality input during inference. However, their effectiveness drops sharply when certain modalities are unavailable or incomplete. Current research on missing modality primarily faces two dilemmas: Prompt-based methods struggle to restore missing yet indispensable features and degrade the generalizability of VLM. Imputation-based approaches, lacking effective guidance, are prone to generating semantically irrelevant noise. Restoring precise semantics while sustaining VLM's generalization remains challenging. Therefore, we propose a general missing modality restoration strategy in this paper. We introduce an enhanced diffusion model as a pluggable mid-stage training module to effectively restore missing features. Our strategy introduces two key innovations: (I) Dynamic Modality Gating, which adaptively leverages conditional features to guide the generation of semantically consistent features; (II) Cross-Modal Mutual Learning mechanism, which bridges the semantic spaces of the dual models to achieve bi-directional alignment. Notably, our strategy maintains the original integrity of the pre-trained VLM, requiring no fine-tuning of the backbone models while significantly boosting resilience to information loss. Zero-shot evaluations across benchmark datasets demonstrate that our approach consistently outperforms existing baselines, establishing it as a robust and scalable extension that ensures VLM reliability across diverse missing rates and conditions. Our code and models will be publicly available.

arXiv:2603.13777v2 Announce Type: replace-cross Abstract: Aspect-based sentiment analysis (ABSA) extracts aspect-level sentiment signals from user-generated text, supports product analytics, experience monitoring, and public-opinion tracking, and is central to fine-grained opinion mining. A key challenge in ABSA is aspect sentiment quad prediction (ASQP), which requires identifying four elements: the aspect term, the aspect category, the opinion term, and the sentiment polarity. However, existing studies usually linearize the unordered quad set into a fixed-order template and decode it left-to-right. With teacher forcing training, the resulting training-inference mismatch (exposure bias) lets early prefix errors propagate to later elements. The linearization order determines which elements appear earlier in the prefix, so this propagation becomes order-sensitive and is hard to repair in a single pass. To address this, we propose a method, Generate-then-Correct (G2C): a generator drafts quads and a corrector performs a single-shot, sequence-level global correction trained on LLM-synthesized drafts with common error patterns. On the Rest15 and Rest16 datasets, G2C outperforms strong baseline models.

arXiv:2603.29386v1 Announce Type: cross Abstract: The rapid democratization of prompt-based AI image editing has recently exacerbated the risks associated with malicious content fabrication and misinformation. However, forgery localization methods targeting these emerging editing techniques remain significantly under-explored. To bridge this gap, we first introduce a fully automated mask annotating framework that leverages keypoint alignment and semantic space similarity to generate precise ground-truth masks for edited regions. Based on this framework, we construct PromptForge-350k, a large-scale forgery localization dataset covering four state-of-the-art prompt-based AI image editing models, thereby mitigating the data scarcity in this domain. Furthermore, we propose ICL-Net, an effective forgery localization network featuring a triple-stream backbone and intra-image contrastive learning. This design enables the model to capture highly robust and generalizable forensic features. Extensive experiments demonstrate that our method achieves an IoU of 62.5% on PromptForge-350k, outperforming SOTA methods by 5.1%. Additionally, it exhibits strong robustness against common degradations with an IoU drop of less than 1%, and shows promising generalization capabilities on unseen editing models, achieving an average IoU of 41.5%.

arXiv:2506.18485v3 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards~(RLVR) has emerged as a powerful learn-to-reason paradigm for large reasoning models to tackle complex tasks. However, the current RLVR paradigm is still not efficient enough, as it works in a trial-and-error manner. To perform better, the model needs to explore the reward space by numerously generating responses and learn from fragmented reward signals, blind to the overall reward patterns. Fortunately, verifiable rewards make the natural language description of the reward function possible, and meanwhile, LLMs have demonstrated strong in-context learning ability. This motivates us to explore if large reasoning models can benefit from a \textbf{motivation} of the task, \textit{i.e.}, awareness of the reward function, during the reinforcement finetuning process, as we humans sometimes do when learning. In this paper, we introduce \textit{\textbf{M}otivation-\textbf{e}nhanced \textbf{R}einforcement \textbf{F}inetuning}~(\textbf{MeRF}), an intuitive yet effective method enhancing reinforcement finetuning of LLMs by involving \emph{``telling LLMs rules of the game''}. Specifically, \textbf{MeRF} directly injects the reward specification into the prompt, which serves as an in-context motivation for the model to be aware of the optimization objective. This simple modification leverages the in-context learning ability of LLMs, aligning generation with optimization, thereby incentivizing the model to generate desired outputs from both inner motivation and external reward. Empirical evaluations demonstrate that \textbf{MeRF} achieves substantial performance gains over the RLVR baseline. Moreover, ablation studies show that MeRF performs better with greater consistency between the in-context motivation and the external reward function, while the model also demonstrates an ability to adapt to misleading motivations through reinforcement finetuning.

arXiv:2602.19844v1 Announce Type: cross Abstract: LLM-enabled applications are rapidly reshaping the software ecosystem by using large language models as core reasoning components for complex task execution. This paradigm shift, however, introduces fundamentally new reliability challenges and significantly expands the security attack surface, due to the non-deterministic, learning-driven, and difficult-to-verify nature of LLM behavior. In light of these emerging and unavoidable safety challenges, we argue that such risks should be treated as expected operational conditions rather than exceptional events, necessitating a dedicated incident-response perspective. Consequently, the primary barrier to trustworthy deployment is not further improving model capability but establishing system-level threat monitoring mechanisms that can detect and contextualize security-relevant anomalies after deployment -- an aspect largely underexplored beyond testing or guardrail-based defenses. Accordingly, this position paper advocates systematic and comprehensive monitoring of security threats in LLM-enabled applications as a prerequisite for reliable operation and a foundation for dedicated incident-response frameworks.