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MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy
Nature Cancer, Published online: 11 September 2026; doi:10.1038/s43018-026-01236-w
Zheng et al. describe how hypoxia-induced methylmalonate semialdehyde dehydrogenase lactylation promotes acyl-CoA synthetase long-chain family member 4 propionylation and degradation, thereby suppressing ferroptosis induced by chemotherapy, and develop a blocking peptide that increased chemotherapy efficacy in pancreatic ductal adenocarcinoma.HiRAD: A Flexible Large-Scale AGV Routing System
From Diet to Disease: The Role of the Gut Microbiome and Microbial Metabolites in Horses
Vet Sci. 2026 Aug 18;13(8):823. doi: 10.3390/vetsci13080823.
ABSTRACT
The equine gastrointestinal microbiome plays an essential role in digestion, energy metabolism, immune regulation, and maintenance of intestinal homeostasis. Increasing evidence suggests that microbial-derived metabolites provide a functional link between diet, the microbiome, and host physiology. This narrative review summarizes current knowledge on how dietary factors, including structural carbohydrates, non-structural carbohydrates, protein, and lipids, influence microbial function and metabolite production in horses. Relevant publications available up to June 2026 were identified through searches of PubMed, Web of Science, Scopus, and Google Scholar and were narratively synthesized according to dietary factors, microbial metabolites, associated diseases, and nutritional interventions. Emphasis is placed on major microbial metabolites, including short-chain fatty acids, endotoxins, bile acid derivatives, tryptophan metabolites, and nitrogenous fermentation products, and their potential roles in health and disease. Current evidence supports a central role for the nutrition-microbiota-metabolite axis in gastrointestinal disorders such as colic, colitis, equine gastric ulcer syndrome, and carbohydrate-associated laminitis, whereas its involvement in equine metabolic syndrome and the gut-lung axis remains less well defined. The review also discusses microbiome-targeted nutritional interventions and emerging multi-omics approaches that are improving our understanding of microbial function. Collectively, these findings highlight the potential of microbiome-informed nutritional strategies to support equine health, welfare, disease prevention, and athletic performance.
PMID:42655843 | PMC:PMC13517798 | DOI:10.3390/vetsci13080823
Cusp-singularity-enhanced Coriolis effect for sensitive chip-scale gyroscopes
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10565-w
By using singularity physics to enable cubic-root scaling of frequency and phase modulations induced by the Coriolis effect to enhance the performance of chip-scale Coriolis vibratory gyroscopes, substantial improvements in signal-to-noise ratio and precision are demonstrated.An activated wheat CCG10-NLR immune receptor forms an octameric resistosome
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6
Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.