Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03979-3

Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer

arXiv:2502.10906v2 Announce Type: replace Abstract: Reward design plays a pivotal role in the training of game AIs, requiring substantial domain-specific knowledge and human effort. In recent years, several studies have explored reward generation for training game agents and controlling robots using large language models (LLMs). In the content generation literature, there has been early work on generating reward functions for reinforcement learning agent generators. This work introduces PCGRLLM, an extended architecture based on earlier work, which employs a feedback mechanism and several reasoning-based prompt engineering techniques. We evaluate the proposed method on a story-to-reward generation task in a two-dimensional environment using two state-of-the-art LLMs across various reasoning-based prompting methods. Our experiments provide insightful evaluations that demonstrate the capabilities of LLMs essential for content generation tasks. The results demonstrate a substantial performance improvement over the previous structure, achieving performance comparable to that of humans. Our work demonstrates the potential to reduce human dependency in game AI development, while supporting and enhancing creative processes.

arXiv:2601.06870v2 Announce Type: replace-cross Abstract: Multimodal large language models have demonstrated strong ability in capturing semantic representations for multimodal sentiment analysis. Their capacity to learn stable and generalizable multimodal features is limited, however, by the scarcity of high-quality training data. To address this, we propose QASA (Quality-Aware Semantic Augmentation), which uses diffusion models to generate augmented visual and auditory samples, thereby enlarging the training dataset and supporting multimodal learning. The generated samples can vary in quality and may exhibit cross-modal inconsistencies. To manage this, we introduce a decoupled quality-aware scoring module that assigns training weights based on the reliability of each augmented sample. This approach reduces the influence of low-quality data and contributes to more stable and robust model training. The framework combines the generative capabilities of diffusion models with the semantic reasoning of multimodal large models, providing an automated data augmentation strategy that does not require human annotation while improving generalization and robustness under limited high-quality data. Experiments on the CH-SIMS dataset show that QASA yields a relative increase of 18.0\% and 5.9\% in five-class accuracy (Acc5) and binary accuracy (Acc2), respectively, and it also outperforms existing methods on the CMU-MOSI and MUStARD benchmarks.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10208-0

A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in IL-2 receptor-expressing T cells and induces stable antigen-specific regulatory T cells in peripheral lymphoid organs.

arXiv:2511.03950v2 Announce Type: replace-cross Abstract: Reconstructing real-world objects from multi-view images is essential for applications in 3D editing, AR/VR, and digital content creation. Existing methods typically prioritize either geometric accuracy (Multi-View Stereo) or photorealistic rendering (Novel View Synthesis), often decoupling geometry and appearance optimization, which hinders downstream editing tasks. This paper advocates an unified treatment on geometry and appearance optimization for seamless Gaussian-mesh joint optimization. More specifically, we propose a novel framework that simultaneously optimizes mesh geometry (vertex positions and faces) and vertex colors via Gaussian-guided mesh differentiable rendering, leveraging photometric consistency from input images and geometric regularization from normal and depth maps. The obtained high-quality 3D reconstruction can be further exploit in down-stream editing tasks, such as relighting and shape deformation. Our code will be released in https://github.com/zhejia01/TexGuided-GS2Mesh