The authors develop AminiCRoff, a compact dAsCas12f1-based epigenetic silencer compatible with single-AAV delivery. AminiCRoff mediates durable, heritable gene silencing comparable to the larger CRISPRoff and represses endogenous MYC to inhibit tumor cell proliferation, providing a versatile platform for in vivo epigenome editing.

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.

arXiv:2603.02886v1 Announce Type: cross Abstract: Most existing Face Forgery Detection (FFD) models assume access to raw face images. In practice, under a client-server framework, private facial data may be intercepted during transmission or leaked by untrusted servers. Previous privacy protection approaches, such as anonymization, encryption, or distortion, partly mitigate leakage but often introduce severe semantic distortion, making images appear obviously protected. This alerts attackers, provoking more aggressive strategies and turning the process into a cat-and-mouse game. Moreover, these methods heavily manipulate image contents, introducing degradation or artifacts that may confuse FFD models, which rely on extremely subtle forgery traces. Inspired by advances in image steganography, which enable high-fidelity hiding and recovery, we propose a Stega}nography-based Face Forgery Detection framework (StegaFFD) to protect privacy without raising suspicion. StegaFFD hides facial images within natural cover images and directly conducts forgery detection in the steganographic domain. However, the hidden forgery-specific features are extremely subtle and interfered with by cover semantics, posing significant challenges. To address this, we propose Low-Frequency-Aware Decomposition (LFAD) and Spatial-Frequency Differential Attention (SFDA), which suppress interference from low-frequency cover semantics and enhance hidden facial feature perception. Furthermore, we introduce Steganographic Domain Alignment (SDA) to align the representations of hidden faces with those of their raw counterparts, enhancing the model's ability to perceive subtle facial cues in the steganographic domain. Extensive experiments on seven FFD datasets demonstrate that StegaFFD achieves strong imperceptibility, avoids raising attackers' suspicion, and better preserves FFD accuracy compared to existing facial privacy protection methods.