arXiv:2604.04701v1 Announce Type: cross Abstract: Large language models (LLMs) have achieved outstanding performance across a wide range of natural language processing tasks, but their enormous parameter counts impose ubstantial memory and computational overheads. This challenge is particularly critical in NPU-based on-device environments, where FP16/FP32 computation is inefficient and integer (INT) quantization is therefore essential. However, existing methods, including ZeroQuant, LLM.int8(), and SmoothQuant, do not fully address input-activation outliers and the associated hardware inefficiencies. To overcome these limitations, we propose MUXQ (Mixed-to-Uniform Quantization). MUXQ detects outlier channels in input activations and introduces a small auxiliary matrix that redistributes outlier magnitudes across channels, thereby alleviating the outlier problem. This enables even activation outliers to be quantized at low-precision INT levels while preserving a hardware-friendly computation structure. Experiments on GPT-2 models at three scales (0.1B, 0.3B, and 0.7B parameters) using the WikiText-2 dataset show that MUXQ consistently achieves lower perplexity than naive quantization. In particular, under per-tensor quantization, MUXQ quantizes both activations and weights to INT8 while maintaining accuracy close to that of FP16. With only modest computational overhead, MUXQ enables stable low-precision inference and can be readily combined with other quantization techniques. These results suggest that MUXQ provides a promising direction for efficient and accurate LLM inference on edge devices.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8

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