Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01780-x

A long-term flexible electrode array system stably tracks individual neurons for months, revealing intrinsic drift in visual evoked neural activity and potentiating durable cross-session and cross-animal decoding.

arXiv:2609.12718v1 Announce Type: new Abstract: Hallucinations can undermine clinician trust in LLMs, making it important that evaluation methods capture clinically relevant errors. Rubric-based evaluation has become the leading approach for assessing LLMs in medicine, but it is unclear whether rubric scores reflect such errors. We first study this in a controlled setting using MedHallu, finding that more specific rubrics better distinguish correct from hallucinated responses. To test this systematically, we develop a taxonomy of medical hallucination types and a clinician-validated error-injection pipeline that creates matched correct and error-injected responses. Across HealthBench, HealthBench Professional, and LiveMedBench, our clinically relevant hallucinations are missed by rubrics, often leaving scores unchanged. We find that rubrics are most effective when explicitly checking facts, and are less effective for additional or unexpected errors they do not anticipate. A preliminary retrieval-based factuality check recovers some of the rubric-blind errors, suggesting a complementary approach. These findings reveal systematic blind spots in current medical evaluation of LLMs and suggest that rubric scores alone are insufficient to establish clinical reliability, potentially undermining clinician trust and confidence in clinical deployment.

arXiv:2609.12533v1 Announce Type: cross Abstract: Real-world Earth observation (EO) agents must translate high-level scientific questions into executable workflows to acquire observations, prepare data, perform domain computations, and derive conclusions from runtime evidence. Existing EO agents typically start from supplied observations, while benchmarks typically provide prepared inputs or candidate answers, leaving full-chain open-world EO execution largely untested. We present Earth-Agent-Pro, an execution-adaptive Plan-and-Execute framework using expert-authored skills to constrain planning and runtime tool use. Workflow-centered structured memory records planned steps, accepted evidence, and their dependencies, enabling repair of only the affected workflow suffix when runtime evidence invalidates a step. Separate large language model adapters use sequence-level supervised fine-tuning for planner workflow composition and node-level group relative policy optimization with locally verifiable rewards for executor tool-argument grounding. Earth-Bench-Pro instantiates 248 expert-curated task cores as 744 questions under three matched regimes. Its 248 Open-World Execution questions span RGB imagery, spectral observations, and remote sensing products, pairing high-level requests with runtime data requirements, executable trajectories, and open-ended answers grounded in execution evidence. With a shared GPT-5 backbone, Earth-Agent-Pro achieves 66.13% LLM-as-Judge accuracy, exceeding ReAct by 20.95 points in this metric and 24.44 points in Tools-In-Order. Joint adapter tuning raises Qwen3.5-9B LLM-as-Judge accuracy from 38.31% to 50.00%, an 11.69-point gain over the untuned configuration. Planning-only evaluation and execution with the reference workflow show that the adapters improve workflow composition and argument grounding, respectively. Code and datasets will be released soon.

arXiv:2604.08988v3 Announce Type: replace Abstract: Current LLM-based agents demonstrate strong performance in episodic task execution but remain constrained by static toolsets and episodic amnesia, failing to accumulate experience across task boundaries. This paper formalizes the Self-Evolving Agent (SEA) from the perspective of digital embodiment and continuous cross-task evolution, introduces the Evolutionary Flywheel as its minimal sufficient architecture, and presents SEA-Eval -- the first benchmark designed specifically for evaluating SEAs. Grounded in Flywheel theory, SEA-Eval establishes SR and T as primary metrics and, through sequential task stream design, is designed to quantify evolutionary gain, evolutionary stability, and implicit alignment convergence. Empirical evaluation reveals that, under comparable success rates, token consumption differs by up to 31.2 times between frameworks on individual tasks, with divergent evolutionary trajectories emerging under sequential analysis -- demonstrating that success rate alone creates a capability illusion and that the sequential convergence of $T$ is the key criterion for distinguishing genuine evolution from pseudo-evolution.

arXiv:2604.04898v1 Announce Type: new Abstract: Proprietary AI systems have recently demonstrated impressive capabilities on complex proof-based problems, with gold-level performance reported at the 2025 International Mathematical Olympiad (IMO). However, the training pipelines behind these systems remain largely undisclosed, and their reliance on large "internal" models and scaffolds makes them expensive to run, difficult to reproduce, and hard to study or improve upon. This raises a central question: can small, open models also be trained to achieve competitive reasoning performance on difficult Olympiad-level math? In this paper, we answer this question by building QED-Nano, a 4B model post-trained for Olympiad-level proofs. Our training recipe has three stages: (1) supervised fine-tuning to imbue good proof-writing styles by distilling from DeepSeek-Math-V2, (2) reinforcement learning (RL) with rubric-based rewards, and (3) expanding RL with a reasoning cache, which decomposes long proofs into iterative summarize-and-refine cycles and enables stronger test-time reasoning. QED-Nano surpasses the proof-generation performance of much larger open models, including Nomos-1 and GPT-OSS-120B, and approaches the performance of proprietary models like Gemini 3 Pro, at a fraction of the inference cost. To support further research on open mathematical reasoning, we release the full QED-Nano pipeline, including the QED-Nano and QED-Nano-SFT models, the FineProofs-SFT and FineProofs-RL datasets, and the training and evaluation code.

arXiv:2604.03299v1 Announce Type: cross Abstract: 3D human pose estimation is a key enabling technology for applications such as healthcare monitoring, human-robot collaboration, and immersive gaming, but real-world deployment remains challenged by viewpoint variations. Existing methods struggle to generalize to unseen camera viewpoints, require large amounts of training data, and suffer from high inference latency. We propose MoViD, a viewpoint-invariant 3D human pose estimation framework that disentangles viewpoint information from motion features. The key idea is to extract viewpoint information from intermediate pose features and leverage it to enhance both the robustness and efficiency of pose estimation. MoViD introduces a view estimator that models key joint relationships to predict viewpoint information, and an orthogonal projection module to disentangle motion and view features, further enhanced through physics-grounded contrastive alignment across views. For real-time edge deployment, MoViD employs a frame-by-frame inference pipeline with a view-aware strategy that adaptively activates flip refinement based on the estimated viewpoint. Evaluations on nine public datasets and newly collected multiview UAV and gait analysis datasets show that MoViD reduces pose estimation error by over 24.2\% compared to state-of-the-art methods, maintains robust performance under severe occlusions with 60\% less training data, and achieves real-time inference at 15 FPS on NVIDIA edge devices.

arXiv:2602.13218v2 Announce Type: replace Abstract: Reinforcement Learning from Verifiable Rewards (RLVR) is bottlenecked by data: existing synthesis pipelines rely on expert-written code or fixed templates, confining growth to instance-level perturbations. We shift the evolvable unit from problem instances to task-family specifications. SSLogic is an agentic meta-synthesis framework in which LLM agents iteratively author and refine executable Generator-Validator pairs inside a closed Generate-Validate-Refine loop, producing families with new rules and difficulty gradients rather than parameter variations of old ones. A Multi-Gate Validation Protocol -- multi-strategy consensus plus Adversarial Blind Review, where independent agents solve each instance by writing and executing code -- filters ill-posed tasks before they enter training. Starting from 400 seed families, two evolution rounds yield 953 families and 21,389 verifiable instances. Three converging comparisons (step-matched, token-matched, and size-controlled on external Enigmata data) consistently show higher training utility of evolved data, with gains of SynLogic +5.2, AIME25 +3.0, and BBH +5.5 on Enigmata. Fine-grained KORBench evaluation reveals selective improvements in logic (+13.2%) and operation (+9.6%), linking structural evolution to downstream gains. Code: https://github.com/AdAstraAbyssoque/Scaling-the-Scaling-Logic

arXiv:2603.28532v2 Announce Type: replace-cross Abstract: Low left ventricular ejection fraction (LEF) frequently remains undetected until progression to symptomatic heart failure, underscoring the need for scalable screening strategies. Although artificial intelligence-enabled electrocardiography (AI-ECG) has shown promise, existing approaches rely solely on end-to-end black-box models with limited interpretability or on tabular systems dependent on commercial ECG measurement algorithms with suboptimal performance. We introduced ECG-based Predictor-Driven LEF (ECGPD-LEF), a structured framework that integrates foundation model-derived diagnostic probabilities with interpretable modeling for detecting LEF from ECG. Trained on the benchmark EchoNext dataset comprising 72,475 ECG-echocardiogram pairs and evaluated in predefined independent internal (n=5,442) and external (n=16,017) cohorts, our framework achieved robust discrimination for moderate LEF (internal AUROC 88.4%, F1 64.5%; external AUROC 86.8%, F1 53.6%), consistently outperforming the official end-to-end baseline provided with the benchmark across demographic and clinical subgroups. Interpretability analyses identified high-impact predictors, including normal ECG, incomplete left bundle branch block, and subendocardial injury in anterolateral leads, driving LEF risk estimation. Notably, these predictors independently enabled zero-shot-like inference without task-specific retraining (internal AUROC 75.3-81.0%; external AUROC 71.6-78.6%), indicating that ventricular dysfunction is intrinsically encoded within structured diagnostic probability representations. This framework reconciles predictive performance with mechanistic transparency, supporting scalable enhancement through additional predictors and seamless integration with existing AI-ECG systems.

(Cell 188, 6283–6300.e1–e10; October 30, 2025)

Background: Stroke is a leading cause of long-term upper limb disability, severely impacting patients’ independence and quality of life. Robot-assisted therapy (RAT) has emerged as a promising, high-intensity rehabilitation alternative. However, conclusions from existing systematic reviews on its efficacy are inconsistent and often lack a holistic framework, limiting their use for guiding personalized clinical decisions. Objective: This study aims to systematically synthesize recent evidence on RAT for upper limb rehabilitation after stroke. Guided by the International Classification of Functioning, Disability and Health framework, it moves beyond singular outcomes to provide a multidimensional evaluation across body function, activity, and participation levels. The review aims to provide stratified guidance for clinical decision-making based on patient- and intervention-specific characteristics, thereby supporting evidence-based practice and informing future research. Methods: This study included systematic reviews and meta-analyses published from January 1, 2019, to December 26, 2025, comparing RAT with conventional therapy for upper limb rehabilitation after stroke. Overall, 6 databases, including PubMed, Web of Science, and Embase, were searched. Two reviewers (XZ and LZ) independently performed study selection, data extraction, and quality assessment using the AMSTAR 2 tool. The synthesis integrated outcome measures and subgroup analyses derived from the included studies. Results: This umbrella review included 21 meta-analyses encompassing 535 randomized controlled trials and 27,598 patients across acute, subacute, and chronic stroke stages. According to AMSTAR 2, 17 reviews were high quality, 3 moderate, and 1 critically low. The synthesis demonstrated that RAT was superior in improving upper limb motor function, but no statistically significant advantages were observed in activities of daily living compared to conventional therapy. Subgroup analyses revealed that treatment effects were influenced by stroke stage, upper limb motor impairment level, and robot type. Conclusions: RAT is an effective intervention for improving upper limb motor function after stroke. However, its benefits are primarily observed at the level of body function, with limited evidence for long-term maintenance. The current evidence is constrained by significant outcome heterogeneity and methodological limitations inherent to umbrella reviews. Future research should validate these findings in broader clinical practice, focus on translating functional gains into sustained improvements in daily activities and participation, and include cost-effectiveness evaluations. Trial Registration: PROSPERO CRD42024497183; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024497183

arXiv:2603.23231v1 Announce Type: new Abstract: Empowering large language models with long-term memory is crucial for building agents that adapt to users' evolving needs. However, prior evaluations typically interleave preference-related dialogues with irrelevant conversations, reducing the task to needle-in-a-haystack retrieval while ignoring relationships between events that drive the evolution of user preferences. Such settings overlook a fundamental characteristic of real-world personalization: preferences emerge gradually and accumulate across interactions within noisy contexts. To bridge this gap, we introduce PERMA, a benchmark designed to evaluate persona consistency over time beyond static preference recall. Additionally, we incorporate (1) text variability and (2) linguistic alignment to simulate erratic user inputs and individual idiolects in real-world data. PERMA consists of temporally ordered interaction events spanning multiple sessions and domains, with preference-related queries inserted over time. We design both multiple-choice and interactive tasks to probe the model's understanding of persona along the interaction timeline. Experiments demonstrate that by linking related interactions, advanced memory systems can extract more precise preferences and reduce token consumption, outperforming traditional semantic retrieval of raw dialogues. Nevertheless, they still struggle to maintain a coherent persona across temporal depth and cross-domain interference, highlighting the need for more robust personalized memory management in agents. Our code and data are open-sourced at https://github.com/PolarisLiu1/PERMA.

arXiv:2603.22153v2 Announce Type: replace-cross Abstract: Recent advances in cross-view geo-localization (CVGL) methods have shown strong potential for supporting unmanned aerial vehicle (UAV) navigation in GNSS-denied environments. However, existing work predominantly focuses on matching UAV views to onboard map tiles, which introduces an inherent trade-off between accuracy and storage overhead, and overlooks the importance of the UAV's heading during navigation. Moreover, the substantial discrepancies and varying overlaps in cross-view scenarios have been insufficiently considered, limiting their generalization to real-world scenarios. In this paper, we present Bearing-UAV, a purely vision-driven cross-view navigation method that jointly predicts UAV absolute location and heading from neighboring features, enabling accurate, lightweight, and robust navigation in the wild. Our method leverages global and local structural features and explicitly encodes relative spatial relationships, making it robust to cross-view variations, misalignment, and feature-sparse conditions. We also present Bearing-UAV-90k, a multi-city benchmark for evaluating cross-view localization and navigation. Extensive experiments show encouraging results that Bearing-UAV yields lower localization error than previous matching/retrieval paradigm across diverse terrains. Our code and dataset will be made publicly available.

arXiv:2508.05880v2 Announce Type: replace-cross Abstract: Affective computing seeks to support the holistic development of artificial intelligence by enabling machines to engage with human emotion. Recent foundation models, particularly large language models (LLMs), have been trained and evaluated on emotion-related tasks, typically using supervised learning with discrete emotion labels. Such evaluations largely focus on surface phenomena, such as recognizing expressed or evoked emotions, leaving open whether these systems reason about emotion in cognitively meaningful ways. Here we ask whether LLMs can reason about emotions through underlying cognitive dimensions rather than labels alone. Drawing on cognitive appraisal theory, we introduce CoRE, a large-scale benchmark designed to probe the implicit cognitive structures LLMs use when interpreting emotionally charged situations. We assess alignment with human appraisal patterns, internal consistency, cross-model generalization, and robustness to contextual variation. We find that LLMs capture systematic relations between cognitive appraisals and emotions but show misalignment with human judgments and instability across contexts.

arXiv:2509.14858v3 Announce Type: replace-cross Abstract: Multistep inference is a bottleneck for real-time generative speech enhancement because flow- and diffusion-based systems learn an instantaneous velocity field and therefore rely on iterative ordinary differential equation (ODE) solvers. We introduce MeanFlowSE, a conditional generative model that learns the average velocity over finite intervals along a trajectory. Using a Jacobian-vector product (JVP) to instantiate the MeanFlow identity, we derive a local training objective that directly supervises finite-interval displacement while remaining consistent with the instantaneous-field constraint on the diagonal. At inference, MeanFlowSE performs single-step generation via a backward-in-time displacement, removing the need for multistep solvers; an optional few-step variant offers additional refinement. On VoiceBank-DEMAND, the single-step model achieves strong intelligibility, fidelity, and perceptual quality with substantially lower computational cost than multistep baselines. The method requires no knowledge distillation or external teachers, providing an efficient, high-fidelity framework for real-time generative speech enhancement. The proposed method is open-sourced at https://github.com/liduojia1/MeanFlowSE.

arXiv:2602.19248v1 Announce Type: cross Abstract: The collection and detection of video anomaly data has long been a challenging problem due to its rare occurrence and spatio-temporal scarcity. Existing video anomaly detection (VAD) methods under perform in open-world scenarios. Key contributing factors include limited dataset diversity, and inadequate understanding of context-dependent anomalous semantics. To address these issues, i) we propose LAVIDA, an end-to-end zero-shot video anomaly detection framework. ii) LAVIDA employs an Anomaly Exposure Sampler that transforms segmented objects into pseudo-anomalies to enhance model adaptability to unseen anomaly categories. It further integrates a Multimodal Large Language Model (MLLM) to bolster semantic comprehension capabilities. Additionally, iii) we design a token compression approach based on reverse attention to handle the spatio-temporal scarcity of anomalous patterns and decrease computational cost. The training process is conducted solely on pseudo anomalies without any VAD data. Evaluations across four benchmark VAD datasets demonstrate that LAVIDA achieves SOTA performance in both frame-level and pixel-level anomaly detection under the zero-shot setting. Our code is available in https://github.com/VitaminCreed/LAVIDA.