arXiv:2605.24636v2 Announce Type: new Abstract: While large language models (LLMs) hold transformative potential for medicine, their reasoning robustness and safety in real-world clinical scenarios remain critically underexplored, particularly in dentistry. Here we introduce GlobalDentBench, the first multinational dental benchmark, featuring a taxonomy that encompasses 14 dental specialties across 88 countries and regions spanning six continents. The benchmark comprises 8,978 expert-validated questions across three formats (multiple-choice, short-answer, and case-based questions) and assesses three progressive reasoning levels: knowledge recall (L1), routine reasoning (L2), and individualized reasoning (L3). To ensure data quality, the automated construction framework was calibrated by six senior dentists, achieving expert agreement rates of 99.98% for multiple-choice and short-answer questions and 96.78% for the more complex case-based questions. Evaluation of 12 frontier LLMs on GlobalDentBench revealed a sharp, stepwise performance degradation with increasing reasoning complexity. Specifically, accuracy plummeted from 81.34% on multiple-choice to 64.53% on short-answer and 22.34% on case-based questions, while declining markedly from 74.01% at L1 to 55.64% at L2 and 35.71% at L3. More critically, risk analysis of real-world dental cases demonstrated an alarming overall unsafe rate of 31.01% in LLM-generated clinical recommendations, with 4.51% posing risks of irreversible patient harm and risks particularly pronounced in specialties such as orthodontics. These findings expose fundamental limitations in the medical reasoning and safety of current LLMs. Consequently, GlobalDentBench provides a scalable foundation for trustworthy clinical AI evaluation, underscoring the urgent need for rigorous validation before the safe deployment of these models in healthcare.

An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 signaling axis.

arXiv:2603.03727v1 Announce Type: cross Abstract: This paper studies how parents want to moderate children's interactions with Generative AI chatbots, with the goal of informing the design of future GenAI parental control tools. We first used an LLM to generate synthetic child-GenAI chatbot interaction scenarios and worked with four parents to validate their realism. From this dataset, we carefully selected 12 diverse examples that evoked varying levels of concern and were rated the most realistic. Each example included a prompt and a GenAI chatbot response. We presented these to parents (N=24) and asked whether they found them concerning, why, and how they would prefer the responses to be modified and communicated. Our findings reveal three key insights: (1) parents express concern about interactions that current GenAI chatbot parental controls neglect; (2) parents want fine-grained transparency and moderation at the conversation level; and (3) parents need personalized controls that adapt to their desired strategies and children's ages.