npj Digital Medicine, Published online: 05 October 2026; doi:10.1038/s41746-026-03232-x

Standardized pre-consultation by a large language model agent vs ophthalmology residents: a randomized clinical trial

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10535-2

An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.

arXiv:2604.03679v1 Announce Type: cross Abstract: Large language models (LLMs) excel at complex reasoning, yet their efficiency is limited by the surging cognitive overhead of long thought traces. In this paper, we propose LightThinker, a method that enables LLMs to dynamically compress intermediate thoughts into compact semantic representations. However, static compression often struggles with complex reasoning where the irreversible loss of intermediate details can lead to logical bottlenecks. To address this, we evolve the framework into LightThinker++, introducing Explicit Adaptive Memory Management. This paradigm shifts to behavioral-level management by incorporating explicit memory primitives, supported by a specialized trajectory synthesis pipeline to train purposeful memory scheduling. Extensive experiments demonstrate the framework's versatility across three dimensions. (1) LightThinker reduces peak token usage by 70% and inference time by 26% with minimal accuracy loss. (2) In standard reasoning, LightThinker++ slashes peak token usage by 69.9% while yielding a +2.42% accuracy gain under the same context budget for maximum performance. (3) Most notably, in long-horizon agentic tasks, it maintains a stable footprint beyond 80 rounds (a 60%-70% reduction), achieving an average performance gain of 14.8% across different complex scenarios. Overall, our work provides a scalable direction for sustaining deep LLM reasoning over extended horizons with minimal overhead.

arXiv:2603.13777v2 Announce Type: replace-cross Abstract: Aspect-based sentiment analysis (ABSA) extracts aspect-level sentiment signals from user-generated text, supports product analytics, experience monitoring, and public-opinion tracking, and is central to fine-grained opinion mining. A key challenge in ABSA is aspect sentiment quad prediction (ASQP), which requires identifying four elements: the aspect term, the aspect category, the opinion term, and the sentiment polarity. However, existing studies usually linearize the unordered quad set into a fixed-order template and decode it left-to-right. With teacher forcing training, the resulting training-inference mismatch (exposure bias) lets early prefix errors propagate to later elements. The linearization order determines which elements appear earlier in the prefix, so this propagation becomes order-sensitive and is hard to repair in a single pass. To address this, we propose a method, Generate-then-Correct (G2C): a generator drafts quads and a corrector performs a single-shot, sequence-level global correction trained on LLM-synthesized drafts with common error patterns. On the Rest15 and Rest16 datasets, G2C outperforms strong baseline models.

arXiv:2602.10604v2 Announce Type: replace-cross Abstract: We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.