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Safety, efficacy and acceptability of human-GenAI single-session exposure-based intervention for academic anxiety: randomized controlled trials
npj Digital Medicine, Published online: 12 September 2026; doi:10.1038/s41746-026-03199-9
Safety, efficacy and acceptability of human-GenAI single-session exposure-based intervention for academic anxiety: randomized controlled trialsThe DreAM-plus integrative RNA switch enhances transient AAV expression and reduces side effects of gene editing
Structured light–matter interaction in semiconductor cavity quantum electrodynamics
Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02275-1
Structured light–matter interaction at the single-photon level is demonstrated in a coupled quantum-dot–micropillar system, enabling cavity-enhanced single-photon emission with spin-locked orbital angular momentum and tunable spin–orbit entanglement.DR-LoRA: Dynamic Rank LoRA for Fine-Tuning Mixture-of-Experts Models
AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM(2.5) exposure
Nat Commun. 2026 Mar 30. doi: 10.1038/s41467-026-71196-3. Online ahead of print.
ABSTRACT
Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this association using population-level epidemiological analyses and perform genome-wide association studies (GWAS) to identify genetic variants that modulate infection risk under PM2.5 exposure. In addition, we identify NPC1 as a key modulator involved in SARS-CoV-2 infection efficiency under virus-laden PM2.5 exposure through integrative functional genomic analyses and in vitro experiments. Our findings suggest that PM2.5 facilitates viral entry through an NPC1-modulated endo-lysosomal pathway, providing a mechanistic explanation for observed pollution-related susceptibility. By integrating artificial intelligence (AI)-guided transcriptomics, epidemiology, GWAS, functional genomics, and in vitro verification, our study elucidates how environmental and genetic factors jointly influence SARS-CoV-2 susceptibility. This work highlights how AI-assisted multi-omics integration systematically decodes the health impacts of environmental exposures from molecular to population levels and informs air quality policy and infectious disease preparedness.
PMID:41912520 | DOI:10.1038/s41467-026-71196-3