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Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome

βœ‡Nature - Issue - nature.com science feeds
By: Jianping Liu Β· Jing Zhao Β· Jiayang Gao Β· Kun Zhao Β· Yaoyao Han Β· Jing Yang Β· Zefei Li Β· Jianyu Ye Β· Ziyu Sun Β· Fengyi Wang Β· Xinyi Liu Β· Zekai Li Β· Siyu Ji Β· Bo Liu Β· Cong Liu Β· Yixiao Zhang Β· Junying Yuan Β· James J. Chou

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-ΞΊB signalling.
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A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors

βœ‡Nature Biotechnology - Issue - nature.com science feeds
By: Xiaotian Zhao Β· Weiqiang Jing Β· Ganyu Wang Β· Zhanyan Liu Β· Xinxin Xu Β· Maosen Han Β· Zhipeng Fu Β· Yulin Zhang Β· Zuolin Zheng Β· Jing Zhang Β· Longyu Bo Β· Xianghui Dong Β· Caiping Li Β· Yanhua Sun Β· Junfeng Zhang Β· Fabao Zhao Β· Nianzeng Xing Β· Kun Zhao Β· Xinyi Jiang

Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9

A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.
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