Towards causal validation and clinical translation of the PAK2-fibroblast axis in idiopathic pulmonary fibrosis
Eur Respir J. 2026 Mar 19;67(3):2502148. doi: 10.1183/13993003.02148-2025. Print 2026 Mar.
ABSTRACT
While PAK2 marks fibrotic fibroblast niches in IPF, causal validation, multicellular contextualisation and lung-targeted delivery are required before clinical translation. Spatial omics should guide not only discovery but also therapeutic decision-making. https://bit.ly/4hqQS3F
PMID:41856567 | PMC:PMC13000392 | DOI:10.1183/13993003.02148-2025