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Impact of LLM-supported patient education on patient perspectives and patient-reported outcomes: a mixed-methods systematic review

✇npj Digital Medicine
By: Jiayi Liu · Yanan Zhang · Honghao Lai · Min Han · Ning Ma · Sibo Du · Weilong Zhao · Danni Xia · Bo Tong · Yanru Liu · Bei Pan · Xiaoman Wang · Bingyi Wang · Xufei Luo · Yimeng Li · Janne Estill · Sheng Li · Hongfei Cui · Li Xiao · Long Ge

npj Digital Medicine, Published online: 10 September 2026; doi:10.1038/s41746-026-03228-7

Impact of LLM-supported patient education on patient perspectives and patient-reported outcomes: a mixed-methods systematic review
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MITF-SCD1 Lipid Metabolic Axis Prevents Ouabain-Induced Spiral Ganglion Neuron Ferroptosis and Hearing Loss

✇Molecular Therapy
By: Xue Wang · Fang Chen · Ziji Zhang · Man Zhang · Man Wang · Lei Chen · Anqi Suo · Xugang Zhuang · Tenghan Ling · Renjie Chai · Haibo Wang · Bo Chu · Lei Xu · Wenwen Liu
Ouabain triggers cochlear spiral ganglion neuron (SGN) ferroptosis and hearing loss via SCD1 downregulation. MITF directly activates Scd1 transcription, and the MITF–SCD1 axis mitigates SGN ferroptosis and hearing impairment in ototoxic ouabain and cisplatin models, revealing a lipid metabolic vulnerability and therapeutic target for sensorineural hearing loss.
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