arXiv:2609.13009v1 Announce Type: new Abstract: Low reported scores on leading physics benchmarks, including those featured in the Artificial Analysis Intelligence Index (2026), suggest that frontier language models still struggle with advanced physics, a demanding test of their scientific reasoning and quantitative problem-solving abilities. Yet this impression does not always align with domain experts' experiences using these models in their work. We revisit these reported findings by evaluating frontier models on six widely used physics benchmarks and auditing them with experts, focusing on text-only problems with verifiable final answers. For each subfield of physics, faculty and graduate researchers with relevant expertise carefully review problem statements, reference solutions, and model responses to distinguish genuine model errors from grader errors, incorrect reference solutions, and ambiguous or underspecified questions. Most audited cases initially evaluated as incorrect reflect these benchmarking issues rather than errors in the models' physics reasoning. We then ask experts to address these benchmarking issues by correcting erroneous reference solutions and repairing or excluding flawed questions. We find that GPT-5.6-Sol's measured mean@4 rises from 47.3% to 78.7% on HLE-Physics and from 61.0% to 87.2% on CMT-Benchmark, while its corrected pass@4 reaches 94.4% on the 54 retained CritPt challenges. Corrected scores are computed on the retained evaluation subsets following expert review. Scores on the audited subsets of UGPhysics, PRISM-Physics, and PHYBench also rise substantially after correction. These findings suggest that current benchmarks substantially understate frontier models' ability to solve well-posed physics problems. Near-saturation on these closed-ended tasks highlights the need for more demanding, expert-validated evaluations.

arXiv:2609.04355v2 Announce Type: replace-cross Abstract: Pretrained vision-language-action (VLA) models enable broad manipulation but remain unreliable in tasks demanding precision and repeatability. Applying real-world online reinforcement learning (RL) to VLA post-training enables autonomous trial-and-error improvement beyond demonstrations alone, but exposes two bottlenecks: 1) unreliable value signals can induce policy drift; 2) large-VLA overhead constrains throughput and sample efficiency. To address these challenges, we present VLA-Precision, an efficient real-world online RL framework featuring the Asymmetric Co-Bootstrapping (ACoB) algorithm and the ACoB-Stream architecture. Specifically, ACoB establishes asymmetric co-bootstrapping across timescales: early intervention-guided behavioral learning rapidly improves policy performance while enhancing online experience quality. As autonomous experience accumulates, global return propagation and local preference ranking progressively calibrate value estimates, yielding relative action advantages for reference-regularized policy improvement while suppressing drift. To enable ACoB on large VLAs, we develop ACoB-Stream, a closed-loop experience--policy architecture that establishes invariant-state decoupling and on-demand streaming as design principles, delivering up to 10.9$\times$ improvements in throughput and computational efficiency. Extensive evaluations on nine high-precision chemistry tasks across four categories and four robot embodiments show that VLA-Precision achieves 98.3\% mean success rate in 45.8 min/task, with 27.6 s episodes running at 1.2$\times$ and 1.8$\times$ the speeds of VLA and RL baselines. Resources are available at https://vla-precision.github.io.

Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7

The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation

arXiv:2505.18190v5 Announce Type: replace-cross Abstract: Physics sensing plays a central role in many scientific and engineering domains, which inherently involves two coupled tasks: reconstructing dense physical fields from sparse observations and optimizing scattered sensor placements to observe maximum information. While deep learning has made rapid advances in sparse-data reconstruction, existing methods generally omit optimization of sensor placements, leaving the mutual enhancement between reconstruction and placement on the shelf. To change this suboptimal practice, we propose PhySense, a synergistic two-stage framework that learns to jointly reconstruct physical fields and to optimize sensor placements, both aiming for accurate physics sensing. The first stage involves a flow-based generative model enhanced by cross-attention to adaptively fuse sparse observations. Leveraging the reconstruction feedback, the second stage performs sensor placement via projected gradient descent to satisfy spatial constraints. We further prove that the learning objectives of the two stages are consistent with classical variance-minimization principles, providing theoretical guarantees. Extensive experiments across three challenging benchmarks, especially a 3D geometry dataset, indicate PhySense achieves state-of-the-art physics sensing accuracy and discovers informative sensor placements previously unconsidered. Code is available at this repository: https://github.com/thuml/PhySense.

arXiv:2511.12046v2 Announce Type: replace-cross Abstract: Knowledge Distillation (KD) is essential for compressing large models, yet relying on pre-trained "teacher" models downloaded from third-party repositories introduces serious security risks--most notably backdoor attacks. Existing KD backdoor methods are typically complex and computationally intensive: they employ surrogate student models and simulated distillation to guarantee transferability, and construct triggers similar to universal adversarial perturbations (UAPs), which being not stealthy in magnitude, inherently exhibit strong adversarial behavior. This work questions whether such complexity is necessary and constructs stealthy "weak" triggers--imperceptible perturbations that have negligible adversarial effect. We propose BackWeak, a simple, surrogate-free attack paradigm. BackWeak shows that a powerful backdoor can be implanted by simply fine-tuning a benign teacher with a weak trigger using a very small learning rate. We demonstrate that this delicate fine-tuning is sufficient to embed a backdoor that reliably transfers to diverse student architectures during a victim's standard distillation process, yielding high attack success rates. Extensive empirical evaluations on multiple datasets, model architectures, and KD methods show that BackWeak is efficient, simpler, and often more stealthy than previous elaborate approaches. This work calls on researchers studying KD backdoor attacks to pay particular attention to the trigger's potential adversarial characteristics.

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6

Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0

A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

arXiv:2603.04951v2 Announce Type: replace Abstract: While RAG has greatly enhanced LLMs, extending this paradigm to Time-Series Foundation Models (TSFMs) remains a challenge. This is exemplified in the Predictive Maintenance of the Pressure Regulating and Shut-Off Valve (PRSOV), a high-stakes industrial scenario characterized by (1) data scarcity, (2) short transient sequences, and (3) covariate coupled dynamics. Unfortunately, existing time-series RAG approaches predominantly rely on generated static vector embeddings and learnable context augmenters, which may fail to distinguish similar regimes in such scarce, transient, and covariate coupled scenarios. To address these limitations, we propose RAG4CTS, a regime-aware, training-free RAG framework for Covariate Time-Series. Specifically, we construct a hierarchal time-series native knowledge base to enable lossless storage and physics-informed retrieval of raw historical regimes. We design a two-stage bi-weighted retrieval mechanism that aligns historical trends through point-wise and multivariate similarities. For context augmentation, we introduce an agent-driven strategy to dynamically optimize context in a self-supervised manner. Extensive experiments on PRSOV demonstrate that our framework significantly outperforms state-of-the-art baselines in prediction accuracy. The proposed system is deployed in Apache IoTDB within China Southern Airlines. Since deployment, our method has successfully identified one PRSOV fault in two months with zero false alarm.

arXiv:2603.08262v1 Announce Type: new Abstract: The integration of Large Language Models (LLMs) into the financial domain is driving a paradigm shift from passive information retrieval to dynamic, agentic interaction. While general-purpose tool learning has witnessed a surge in benchmarks, the financial sector, characterized by high stakes, strict compliance, and rapid data volatility, remains critically underserved. Existing financial evaluations predominantly focus on static textual analysis or document-based QA, ignoring the complex reality of tool execution. Conversely, general tool benchmarks lack the domain-specific rigor required for finance, often relying on toy environments or a negligible number of financial APIs. To bridge this gap, we introduce FinToolBench, the first real-world, runnable benchmark dedicated to evaluating financial tool learning agents. Unlike prior works limited to a handful of mock tools, FinToolBench establishes a realistic ecosystem coupling 760 executable financial tools with 295 rigorous, tool-required queries. We propose a novel evaluation framework that goes beyond binary execution success, assessing agents on finance-critical dimensions: timeliness, intent type, and regulatory domain alignment. Furthermore, we present FATR, a finance-aware tool retrieval and reasoning baseline that enhances stability and compliance. By providing the first testbed for auditable, agentic financial execution, FinToolBench sets a new standard for trustworthy AI in finance. The tool manifest, execution environment, and evaluation code will be open-sourced to facilitate future research.

arXiv:2603.06726v1 Announce Type: cross Abstract: Electricity market prices exhibit extreme volatility, nonlinearity, and non-stationarity, making accurate forecasting a significant challenge. While cutting-edge time series foundation models (TSFMs) effectively capture temporal dependencies, they typically underutilize cross-variate correlations and non-periodic patterns that are essential for price forecasting. Conversely, regression models excel at capturing feature interactions but are limited to future-available inputs, ignoring crucial historical drivers that are unavailable at forecast time. To bridge this gap, we propose FutureBoosting, a novel paradigm that enhances regression-based forecasts by integrating forecasted features generated from a frozen TSFM. This approach leverages the TSFM's ability to model historical patterns and injects these insights as enriched inputs into a downstream regression model. We instantiate this paradigm into a lightweight, plug-and-play framework for electricity price forecasting. Extensive evaluations on real-world electricity market data demonstrate that our framework consistently outperforms state-of-the-art TSFMs and regression baselines, achieving reductions in Mean Absolute Error (MAE) of more than 30% at most. Through ablation studies and explainable AI (XAI) techniques, we validate the contribution of forecasted features and elucidate the model's decision-making process. FutureBoosting establishes a robust, interpretable, and effective solution for practical market participation, offering a general framework for enhancing regression models with temporal context.

Cell Death Discovery, Published online: 06 March 2026; doi:10.1038/s41420-026-02994-3

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation

arXiv:2512.22420v4 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing speculative decoding methods use fixed lengths and cannot adapt to workload changes or decide when to stop speculation. The cost of restarting speculative inference also remains unquantified. Under high load, the benefit of speculation diminishes, while retaining the draft model reduces KV-cache capacity, limiting batch size and degrading throughput. To overcome this, we propose Nightjar, a resource-aware adaptive speculative framework. It first adjusts to the request load by dynamically selecting the optimal speculative length for different batch sizes. Crucially, Nightjar proactively disables speculative decoding when the MAB planner determines that speculation is no longer beneficial, and during the disabled phase, offloads the draft model to the CPU only under GPU memory pressure. This reclaims memory for the KV cache, thereby facilitating larger batch sizes and maximizing overall system throughput. Experiments show that Nightjar achieves average 27.29% higher throughput and up to 20.18% lower latency compared to standard speculative decoding under dynamic request arrival rates in real-time LLM serving scenarios.

arXiv:2512.22420v3 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Existing Speculative Decoding strategies typically rely on static speculative lengths, failing to adapt to fluctuating request loads or identify the optimal moment to halt speculation. The cost of restarting speculative inference also remains unquantified. During traffic surges, the marginal utility of speculation diminishes; yet, the draft model's persistent memory footprint competes for available KV cache. This resource contention limits the maximum batch size, thereby degrading overall system throughput. To overcome this, we propose Nightjar, a resource-aware adaptive speculative framework. It first adjusts to the request load by dynamically selecting the optimal speculative length for different batch sizes. Crucially, upon detecting significant request queuing or KV cache shortages, it disables speculative decoding and offloads the draft model to the CPU. This reclaims memory for the KV cache, thereby facilitating larger batch sizes and maximizing overall system throughput. Experiments show that Nightjar achieves up to 27.29% higher throughput and 12.90% lower latency compared to standard speculative decoding under dynamic request arrival rates in real-time LLM serving scenarios.

arXiv:2602.14338v1 Announce Type: cross Abstract: Reinforcement learning (RL) plays a central role in large language model (LLM) post-training. Among existing approaches, Group Relative Policy Optimization (GRPO) is widely used, especially for RL with verifiable rewards (RLVR) fine-tuning. In GRPO, each query prompts the LLM to generate a group of rollouts with a fixed group size $N$. When all rollouts in a group share the same outcome, either all correct or all incorrect, the group-normalized advantages become zero, yielding no gradient signal and wasting fine-tuning compute. We introduce Adaptive Efficient Rollout Optimization (AERO), an enhancement of GRPO. AERO uses an adaptive rollout strategy, applies selective rejection to strategically prune rollouts, and maintains a Bayesian posterior to prevent zero-advantage dead zones. Across three model configurations (Qwen2.5-Math-1.5B, Qwen2.5-7B, and Qwen2.5-7B-Instruct), AERO improves compute efficiency without sacrificing performance. Under the same total rollout budget, AERO reduces total training compute by about 48% while shortening wall-clock time per step by about 45% on average. Despite the substantial reduction in compute, AERO matches or improves Pass@8 and Avg@8 over GRPO, demonstrating a practical, scalable, and compute-efficient strategy for RL-based LLM alignment.

arXiv:2512.22420v2 Announce Type: replace-cross Abstract: Speculative decoding (SD) accelerates LLM inference by verifying draft tokens in parallel. However, this method presents a critical trade-off: it improves throughput in low-load, memory-bound systems but degrades performance in high-load, compute-bound environments due to verification overhead. Current SD implementations use a fixed speculative length, failing to adapt to dynamic request rates and creating a significant performance bottleneck in real-world serving scenarios. To overcome this, we propose Nightjar, a novel learning-based algorithm for adaptive speculative inference that adjusts to request load by dynamically selecting the optimal speculative length for different batch sizes and even disabling speculative decoding when it provides no benefit. Experiments show that Nightjar achieves up to 14.8% higher throughput and 20.2% lower latency compared to standard speculative decoding, demonstrating robust efficiency for real-time serving.