Lyu et al. identify the STING-ER-exit motif and the mechanism of its recognition by the COPII vesicle cargo-binding protein SEC24C. This study reveals how STING achieves controlled rather than constitutive ER exit and how COPII cargo recognition of STING can be modulated to control STING signaling.

arXiv:2604.04815v1 Announce Type: cross Abstract: The rapid development of Large Language Models (LLMs) has transformed fake news detection and fact-checking tasks from simple classification to complex reasoning. However, evaluation frameworks have not kept pace. Current benchmarks are static, making them vulnerable to benchmark data contamination (BDC) and ineffective at assessing reasoning under temporal uncertainty. To address this, we introduce LiveFact a continuously updated benchmark that simulates the real-world "fog of war" in misinformation detection. LiveFact uses dynamic, temporal evidence sets to evaluate models on their ability to reason with evolving, incomplete information rather than on memorized knowledge. We propose a dual-mode evaluation: Classification Mode for final verification and Inference Mode for evidence-based reasoning, along with a component to monitor BDC explicitly. Tests with 22 LLMs show that open-source Mixture-of-Experts models, such as Qwen3-235B-A22B, now match or outperform proprietary state-of-the-art systems. More importantly, our analysis finds a significant "reasoning gap." Capable models exhibit epistemic humility by recognizing unverifiable claims in early data slices-an aspect traditional static benchmarks overlook. LiveFact sets a sustainable standard for evaluating robust, temporally aware AI verification.

arXiv:2506.03922v3 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) have demonstrated significant potential to advance a broad range of domains. However, current benchmarks for evaluating MLLMs primarily emphasize general knowledge and vertical step-by-step reasoning typical of STEM disciplines, while overlooking the distinct needs and potential of the Humanities and Social Sciences (HSS). Tasks in the HSS domain require more horizontal, interdisciplinary thinking and a deep integration of knowledge across related fields, which presents unique challenges for MLLMs, particularly in linking abstract concepts with corresponding visual representations. Addressing this gap, we present HSSBench, a dedicated benchmark designed to assess the capabilities of MLLMs on HSS tasks in multiple languages, including the six official languages of the United Nations. We also introduce a novel data generation pipeline tailored for HSS scenarios, in which multiple domain experts and automated agents collaborate to generate and iteratively refine each sample. HSSBench contains over 13,000 meticulously designed samples, covering six key categories. We benchmark more than 20 mainstream MLLMs on HSSBench and demonstrate that it poses significant challenges even for state-of-the-art models. We hope that this benchmark will inspire further research into enhancing the cross-disciplinary reasoning abilities of MLLMs, especially their capacity to internalize and connect knowledge across fields.