Oncogene, Published online: 05 March 2026; doi:10.1038/s41388-026-03713-z

KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer

arXiv:2602.18740v1 Announce Type: cross Abstract: This study presents a hierarchical, network-level traffic flow control framework for mixed traffic consisting of Human-driven Vehicles (HVs), Connected and Automated Vehicles (CAVs). The framework jointly optimizes vehicle-level eco-driving behaviors and intersection-level traffic signal control to enhance overall network efficiency and decrease energy consumption. A decentralized Multi-Agent Reinforcement Learning (MARL) approach by Value Decomposition Network (VDN) manages cycle-based traffic signal control (TSC) at intersections, while an innovative Signal Phase and Timing (SPaT) prediction method integrates a Machine Learning-based Trajectory Planning Algorithm (MLTPA) to guide CAVs in executing Eco-Approach and Departure (EAD) maneuvers. The framework is evaluated across varying CAV proportions and powertrain types to assess its effects on mobility and energy performance. Experimental results conducted in a 4*4 real-world network demonstrate that the MARL-based TSC method outperforms the baseline model (i.e., Webster method) in speed, fuel consumption, and idling time. In addition, with MLTPA, HONEST-CAV benefits the traffic system further in energy consumption and idling time. With a 60% CAV proportion, vehicle average speed, fuel consumption, and idling time can be improved/saved by 7.67%, 10.23%, and 45.83% compared with the baseline. Furthermore, discussions on CAV proportions and powertrain types are conducted to quantify the performance of the proposed method with the impact of automation and electrification.

arXiv:2602.13685v1 Announce Type: cross Abstract: Large Audio Language Models (LALMs) excel at perception but struggle with complex reasoning requiring precise acoustic measurements. While external tools can extract fine-grained features like exact tempo or pitch, effective integration remains challenging: naively using all tools causes information overload, while prompt-based selection fails to assess context-dependent utility. To address this, we propose AuTAgent (Audio Tool Agent), a reinforcement learning framework that learns when and which tools to invoke. By employing a sparse-feedback training strategy with a novel Differential Reward mechanism, the agent learns to filter out irrelevant tools and invokes external assistance only when it yields a net performance gain over the base model. Experimental results confirm that AuTAgent complements the representation bottleneck of LALMs by providing verifiable acoustic evidence. It improves accuracy by 4.20% / 6.20% and 9.80% / 8.00% for open-source and closed-source backbones on the MMAU Test-mini and the MMAR benchmarks, respectively. In addition, further experiments demonstrate exceptional transferability. We highlight the complementary role of external tools in augmenting audio model reasoning.