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Denisovans from southwestern China and their subsistence strategies
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4
Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights into their ecology, behaviour and cultural legacy in eastern Asia.Mode-as-Sequence: Translating Multimodal Motion Prediction into Unified Sequential Mode Modeling
Rethinking Weak Supervision in Anomaly Detection: A Comprehensive Benchmark
Safety in Embodied AI: A Survey of Risks, Attacks, and Defenses
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x
A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.Grokking as Dimensional Phase Transition in Neural Networks
Overcoming missing data in spatial metabolomics with machine learning imputation to accelerate downstream discovery
iScience. 2026 Mar 3;29(4):115203. doi: 10.1016/j.isci.2026.115203. eCollection 2026 Apr 17.
ABSTRACT
Mass spectrometry imaging (MSI)-based spatial metabolomics exhibits extensive missing values; yet, practical guidance on how imputation choices affect both imputation accuracy and downstream spatial analyses remains limited. In this study, we evaluated eight imputation methods, including both existing approaches and a graph convolutional network (GCN)-based method specifically designed for spatial metabolomics data, to identify suitable approaches for spatial metabolomics. To enable comprehensive assessment, we developed an evaluation framework focusing on two objective criteria: (a) imputation accuracy and (b) preservation of spatial cluster structure. We assembled six benchmark datasets spanning mouse brain and liver, human kidney and stomach, and plant seed sections, and conducted controlled dropout simulations of missing values. Across both evaluation dimensions, including imputation accuracy and preservation of spatial cluster structure, RF ranked first overall, and GCN ranked second in both dimensions. Overall, this systematic, dual-perspective benchmark study provides guidance for selecting imputation strategies in spatial metabolomics research.
PMID:41869568 | PMC:PMC12999350 | DOI:10.1016/j.isci.2026.115203