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Beyond ID Embeddings: Process-Grounded Language Modeling for Cognitive Diagnosis

arXiv:2609.12403v1 Announce Type: new Abstract: Cognitive Diagnosis Models (CDMs) play a pivotal role in personalized online learning. Traditional CDMs rely on discrete, ID-based embeddings to represent students, exercises, and concepts. This paradigm diverges from the nature of learner cognition, where knowledge is not stored and retrieved as isolated symbols. As a result, CDMs suffer from semantic limitations when new exercises or concepts appear. In this paper, we propose a Process-aware Language Cognitive Diagnosis (PLCD) framework that uses language-derived structures as cognitive priors and response records to calibrate student posterior states. PLCD leverages large language models (LLMs) to construct concept schemas and cognitive process graphs, and uses target-conditioned semantic memory to retrieve historical responses that are relevant to each target exercise. A process-grounded Language-to-Cognition Mapper with DA-MoE experts and process-level contrastive learning then maps the textual evidence into a unified cognitive space. Experimental results show that PLCD not only outperforms traditional baselines in predicting student performance but also exhibits strong cognitive transfer capabilities. These results connect the computational power of LLMs with the psychometric goal of measuring latent knowledge states, suggesting that structured language priors calibrated by response records can improve cold-start robustness and cognitive grounding.
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Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine

Complete biosynthetic pathways for cephalotaxinone and homoerythratine were elucidated from the endangered plant Cephalotaxus fortunei. Thirteen key enzymes were identified, including two homologous cytochrome P450 enzymes that catalyze a rare divergent oxidation process governing alkaloid scaffold diversification. Full pathway reconstitution in Nicotiana benthamiana establishes a foundation for the sustainable production of the anticancer agent homoharringtonine.
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Claw-Anything: Benchmarking Always-On Personal Assistants with Broader Access to User's Digital World

arXiv:2605.26086v1 Announce Type: new Abstract: Large language model agents are increasingly envisioned as always-on personal assistants with access to anything relevant in the user's digital world. Yet current systems operate over only narrow slices of that world, limiting context-sensitive reasoning and effective assistance. Existing benchmarks similarly provide only partial user state and therefore fail to capture performance in such a broad, always-on setting. To address this gap, we introduce Claw-Anything, a benchmark that expands agent context along three dimensions: long-horizon activity histories, interdependent backend services, and integrated GUI and CLI interaction across multiple devices. To instantiate this setting, we simulate months of user activity through multi-round event injection, producing complex world states and realistic noise, including irrelevant events and conflicting signals. Agents must reason over rich contextual environments while remaining robust to such noise. This expanded scope also enables the evaluation of proactive assistance, requiring agents to anticipate user needs and deliver timely recommendations. Experiments show that GPT-5.5 achieves only 34.5% pass@1, substantially below prior benchmarks, underscoring a gap between current agent capabilities and the demands of always-on personal assistance. Alongside the benchmark, we release an automated data-generation pipeline that yields 2,000 training environments and improves the base model by 23.7%, demonstrating its utility of scalable data infrastructure.
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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review

J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.

ABSTRACT

BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.

METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.

KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.

CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.

PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697

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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review

J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.

ABSTRACT

BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.

METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.

KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.

CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.

PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697

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The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review

J Thorac Dis. 2026 Apr 30;18(4):417. doi: 10.21037/jtd-2025-1-2697. Epub 2026 Mar 26.

ABSTRACT

BACKGROUND AND OBJECTIVE: Lung cancer remains the leading cause of cancer related mortality worldwide, and early detection and precise stratified management are crucial for improving patient outcomes. Tumor growth kinetics, as a characterization of its proliferation and malignant differentiation, is a key decision-making factor and research hotspot in clinical practice today. This study aimed to elucidate the growth kinetics of solid nodular non-small cell lung cancer (NSCLC) as a critical determinant of early diagnosis, prognostic evaluation, and treatment strategy selection, and to address the challenge that significant heterogeneity in tumor growth poses to risk stratification and clinical decision-making.

METHODS: We conducted a retrospective search of PubMed, Embase, Web of Science, and Scopus databases, focusing on the current research status of solid nodular NSCLC, particularly in terms of molecular mechanisms, prognosis, modeling prediction, and management strategies related to its growth heterogeneity, with the aim of exploring future research directions.

KEY CONTENT AND FINDINGS: Volume doubling time (VDT) serves as a key metric for evaluating nodule dynamics. While earlier studies suggested a generally rapid growth pattern (VDT <400 days) in solid nodular NSCLC, recent evidence reveals considerable heterogeneity, with some tumors demonstrating indolent growth pattern (VDT >40-600 days). The prognosis of rapidly growing nodules is usually poor, so nodule management recommendations should be personalized based on growth dynamics and patient characteristics. Traditional radiological features, and deep learning models show promise for growth risk stratification but require large-scale external validation and refinement. Molecular and pathological studies suggest that the tumor microenvironment and immune cell infiltration may contribute to growth heterogeneity, though direct mechanistic evidence remains limited. Artificial intelligence (AI) based approaches exhibit significant potential in predicting individual tumor growth behavior.

CONCLUSIONS: Growth heterogeneity in solid nodular NSCLC carries substantial clinical significance but remains insufficiently studied. Future research should prioritize imaging based modeling to predict individualized growth dynamics. Integrating multi-omics analyses may help elucidate the molecular factors underlying growth heterogeneity. AI driven risk stratification based on large-scale multi center sequence data can achieve truly personalized and growth oriented management strategies.

PMID:42182806 | PMC:PMC13190150 | DOI:10.21037/jtd-2025-1-2697

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Nonlinear atomic tunnelling boosted by bright squeezed vacuum

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10485-9

Bright squeezed vacuum light boosts nonlinear atomic tunnelling ionization more than 20-fold compared with coherent light, enabling quantum control of strong-field processes without increasing classical intensity.
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Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance

Nature Cancer, Published online: 19 May 2026; doi:10.1038/s43018-026-01174-7

Tang et al. identify cysteinyl leukotriene receptor 1 (CysLTR1) as a critical regulator of tumor-induced myelopoiesis, suggesting CysLTR1 targeting to sensitize tumors to immune checkpoint blockade.
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Engineered immunosuppressive dendritic cells protect against cardiac remodelling

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.
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Superconductivity and electronic structures of nickelate thin film superstructures

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7

Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .
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Can LLMs Learn to Reason Robustly under Noisy Supervision?

arXiv:2604.03993v1 Announce Type: cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) effectively trains reasoning models that rely on abundant perfect labels, but its vulnerability to unavoidable noisy labels due to expert scarcity remains critically underexplored. In this work, we take the first step toward a systematic analysis of noisy label mechanisms in RLVR. In contrast to supervised classification, most RLVR algorithms incorporate a rollout-based condition: a label's influence on training is contingent on whether the current policy can generate rollouts that realize it, a property that naturally extends to noisy labels. Based on this observation, we distinguish two types of noise: inactive noisy labels, which reduce data efficiency, and active noisy labels, which are reinforced and risk skewing the model toward incorrect distributions. From experiments on training with noisy samples, we identify an Early Correctness Coherence phenomenon: although noisy samples begin to lag behind in later stages, accuracy on both clean and noisy samples increases similarly in early training. Motivated by this dynamic, we propose Online Label Refinement (OLR), which progressively corrects potentially noisy labels with majority-voted answers when two conditions hold: a positive slope in the majority answer's rollout pass rate and stable historical consistency across updates, enabling gradual self-correction as the policy improves. We evaluate OLR on six in-distribution mathematical reasoning benchmarks (AIME24/25, AMC, MATH-500, Minerva, and Olympiad) and three out-of-distribution tasks (ARC-c, GPQA-diamond, and MMLU-pro). Across noise ratios from 0.1 to 0.9, OLR consistently improves robustness under both inactive and active noisy-label settings, achieving average gains of 3.6% to 3.9% on in-distribution benchmarks and 3.3% to 4.6% on out-of-distribution evaluations.
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Vero: An Open RL Recipe for General Visual Reasoning

arXiv:2604.04917v2 Announce Type: cross Abstract: What does it take to build a visual reasoner that works across charts, science, spatial understanding, and open-ended tasks? The strongest vision-language models (VLMs) show such broad visual reasoning is within reach, but the recipe behind them remains unclear, locked behind proprietary reinforcement learning (RL) pipelines with non-public data. We introduce Vero, a family of fully open VLMs that matches or exceeds existing open-weight models across diverse visual reasoning tasks. We scale RL data and rewards across six broad task categories, constructing Vero-600K, a 600K-sample dataset from 59 datasets, and designing task-routed rewards that handle heterogeneous answer formats. Vero achieves state-of-the-art performance, improving over four base models by 3.6-5.3 points on average across VeroEval, our suite of 30 challenging benchmarks. Starting from Qwen3-VL-8B-Instruct, Vero outperforms Qwen3-VL-8B-Thinking on 23 of 30 benchmarks without additional proprietary thinking data. When trained from the same base model, Vero-600K exceeds existing RL datasets across task categories. Systematic ablations reveal that different task categories elicit qualitatively distinct reasoning patterns that transfer poorly in isolation, suggesting that broad data coverage is the primary driver of strong RL scaling. All data, code, and models are released.
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RaPA: Enhancing Transferable Targeted Attacks via Random Parameter Pruning

arXiv:2504.18594v3 Announce Type: replace-cross Abstract: Compared to untargeted attacks, targeted transfer-based attack is still suffering from much lower Attack Success Rates (ASRs), although significant improvements have been achieved by kinds of methods, such as diversifying input, stabilizing the gradient, and re-training surrogate models. In this paper, we find that adversarial examples generated by existing methods rely heavily on a small subset of surrogate model parameters, which in turn limits their transferability to unseen target models. Inspired by this, we propose the Random Parameter Pruning Attack (RaPA), which introduces parameter-level randomization during the attack process. At each optimization step, RaPA randomly prunes model parameters to generate diverse yet semantically consistent surrogate variants.We show this parameter-level randomization is equivalent to adding an importance-equalization regularizer, thereby alleviating the over-reliance issue. Extensive experiments across both CNN and Transformer architectures demonstrate that RaPA substantially enhances transferability. In the challenging case of transferring from CNN-based to Transformer-based models, RaPA achieves up to 11.7% higher average ASRs than state-of-the-art baselines(with 33.3% ASRs), while being training-free, cross-architecture efficient, and easily integrated into existing attack frameworks. Code is available in https://github.com/molarsu/RaPA.
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NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy

Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03762-4

NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy
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Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
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LLM-Meta-SR: In-Context Learning for Evolving Selection Operators in Symbolic Regression

arXiv:2505.18602v3 Announce Type: replace-cross Abstract: Large language models (LLMs) have revolutionized algorithm development, yet their application in symbolic regression, where algorithms automatically discover symbolic expressions from data, remains limited. In this paper, we propose a meta-learning framework that enables LLMs to automatically design selection operators for evolutionary symbolic regression algorithms. We first identify two key limitations in existing LLM-based algorithm evolution techniques: lack of semantic guidance and code bloat. The absence of semantic awareness can lead to ineffective exchange of useful code components, while bloat results in unnecessarily complex components; both can hinder evolutionary learning progress or reduce the interpretability of the designed algorithm. To address these issues, we enhance the LLM-based evolution framework for meta-symbolic regression with two key innovations: a complementary, semantics-aware selection operator and bloat control. Additionally, we embed domain knowledge into the prompt, enabling the LLM to generate more effective and contextually relevant selection operators. Our experimental results on symbolic regression benchmarks show that LLMs can devise selection operators that outperform nine expert-designed baselines, achieving state-of-the-art performance. Moreover, the evolved operator can further improve a state-of-the-art symbolic regression algorithm, achieving the best performance among 28 symbolic regression and other machine learning algorithms across 116 regression datasets. This demonstrates that LLMs can exceed expert-level algorithm design for symbolic regression.
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