Science, Ahead of Print.

Oncogene, Published online: 03 April 2026; doi:10.1038/s41388-026-03732-w

The role of Rho-associated coiled-coil kinases (ROCK) in cancer

arXiv:2603.12296v1 Announce Type: cross Abstract: Deep learning has achieved transformative performance across diverse domains, largely driven by the large-scale, high-quality training data. In contrast, the development of brain-computer interfaces (BCIs) is fundamentally constrained by the limited, heterogeneous, and privacy-sensitive neural recordings. Generating synthetic yet physiologically plausible brain signals has therefore emerged as a compelling way to mitigate data scarcity and enhance model capacity. This survey provides a comprehensive review of brain signal generation for BCIs, covering methodological taxonomies, benchmark experiments, evaluation metrics, and key applications. We systematically categorize existing generative algorithms into four types: knowledge-based, feature-based, model-based, and translation-based approaches. Furthermore, we benchmark existing brain signal generation approaches across four representative BCI paradigms to provide an objective performance comparison. Finally, we discuss the potentials and challenges of current generation approaches and prospect future research on accurate, data-efficient, and privacy-aware BCI systems. The benchmark codebase is publicized at https://github.com/wzwvv/DG4BCI.

arXiv:2504.21023v1 Announce Type: cross Abstract: The post-training phase of large language models is essential for enhancing capabilities such as instruction-following, reasoning, and alignment with human preferences. However, it demands extensive high-quality data and poses risks like overfitting, alongside significant computational costs due to repeated post-training and evaluation after each base model update. This paper introduces $Param\Delta$, a novel method that streamlines post-training by transferring knowledge from an existing post-trained model to a newly updated base model with ZERO additional training. By computing the difference between post-trained model weights ($\Theta_\text{post}$) and base model weights ($\Theta_\text{base}$), and adding this to the updated base model ($\Theta'_\text{base}$), we define $Param\Delta$ Model as: $\Theta_{\text{Param}\Delta} = \Theta_\text{post} - \Theta_\text{base} + \Theta'_\text{base}$. This approach surprisingly equips the new base model with post-trained capabilities, achieving performance comparable to direct post-training. We did analysis on LLama3, Llama3.1, Qwen, and DeepSeek-distilled models. Results indicate $Param\Delta$ Model effectively replicates traditional post-training. For example, the $Param\Delta$ Model obtained from 70B Llama3-inst, Llama3-base, Llama3.1-base models attains approximately 95\% of Llama3.1-inst model's performance on average. $Param\Delta$ brings a new perspective on how to fully leverage models in the open-weight community, where checkpoints for base and instruct models are readily available and frequently updated, by providing a cost-free framework to accelerate the iterative cycle of model development.