A pan-neurodegeneration atlas built from multilayer, deep proteomics of 2,279 brain samples across 6 major diseases integrates whole proteome, detergent-insoluble proteome, and posttranslational modifications to enable intra- and inter-disease comparisons to reveal disease-specific subtypes and dysregulated pathways, while identifying shared changes such as GPNMB upregulation and NPTX2 downregulation.

arXiv:2603.08486v1 Announce Type: cross Abstract: Multimodal large language models (MLLMs) face safety misalignment, where visual inputs enable harmful outputs. To address this, existing methods require explicit safety labels or contrastive data; yet, threat-related concepts are concrete and visually depictable, while safety concepts, like helpfulness, are abstract and lack visual referents. Inspired by the Self-Fulfilling mechanism underlying emergent misalignment, we propose Visual Self-Fulfilling Alignment (VSFA). VSFA fine-tunes vision-language models (VLMs) on neutral VQA tasks constructed around threat-related images, without any safety labels. Through repeated exposure to threat-related visual content, models internalize the implicit semantics of vigilance and caution, shaping safety-oriented personas. Experiments across multiple VLMs and safety benchmarks demonstrate that VSFA reduces the attack success rate, improves response quality, and mitigates over-refusal while preserving general capabilities. Our work extends the self-fulfilling mechanism from text to visual modalities, offering a label-free approach to VLMs alignment.