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The Menu Is an Execution Prior: State-Path Tool Menus for Online Agents

arXiv:2609.09395v1 Announce Type: new Abstract: Language models act through tools, yet practical agents face libraries containing thousands of interfaces. We introduce the tool menu as the short, ordered subset of available tools shown to an agent before execution. The agent can call only tools in this menu. Multi-step tasks require the final action and the prerequisite tools that create its inputs in a usable order. Current constructors rank tools by request relevance, which can surface the final action while omitting or delaying less obvious producers. We introduce the state path, a pre-execution route from the observable request state to the desired outcome, and propose State-Path Tool Menu to learn it. Our framework treats the menu as an execution prior over these routes. Its encoder represents which tools can run from the current state, how their outputs satisfy later inputs, and which orders recur in training paths. A retriever covers an executable entry, the missing-input producers, and the final action. A reranker then places producers before consumers. On ToolBench, our menu raises online success from 0.737 to 0.898 and outperforms retrieval, reranking, generation, and routing baselines without changing the agent. The State-Path menu also covers more complete chains with 32 tools than the official list covers with 128, and its success gain persists across executor families with different model capacities. Our code is at https://github.com/Met2348/State-Path.
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Detecting Unfaithful Chain-of-Thought via Circuit-Guided Internal-External Discrepancy

arXiv:2605.25603v1 Announce Type: new Abstract: Chain-of-thought (CoT) reasoning improves the problem-solving ability of large language models (LLMs), but generated reasoning traces may not faithfully reflect the model's actual decision process. Existing CoT unfaithfulness detectors mainly rely on external signals from generated rationales, such as textual plausibility or answer consistency, while overlooking evidence from the model's internal computation. Although recent circuit tracing methods provide a way to obtain model-internal evidence by tracing how information flows through model components during reasoning, constructing full reasoning circuits for long CoTs is costly and difficult to scale. To address these challenges, we propose Circuit-guided Internal-External Discrepancy Scorer (CIE-Scorer), a framework for instance-level CoT unfaithfulness detection. The key idea is that faithful reasoning traces should align with the model's computational process, whereas unfaithful traces may diverge from it. CIE-Scorer efficiently traces compact sentence-level circuits from informative reasoning tokens, constructs internal and external reasoning graphs, and measures their discrepancy using Fused Gromov--Wasserstein distance. Experiments on four datasets from FaithCoT-Bench show that CIE-Scorer achieves state-of-the-art performance while reducing the cost of circuit construction, demonstrating the effectiveness of combining mechanistic interpretability signals with external reasoning traces for CoT unfaithfulness detection.
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LiveMCP-101: Stress Testing and Diagnosing MCP-enabled Agents on Challenging Queries

arXiv:2508.15760v2 Announce Type: replace-cross Abstract: Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to discover and invoke tools dynamically. However, there is a significant gap in benchmarking multi-step tasks using diverse MCP tools in realistic, dynamic scenarios. In this work, we present LiveMCP-101, a benchmark of 101 real-world queries that require coordinated use of multiple MCP tools. To address temporal variability in real-world tool responses, we introduce a parallel evaluation framework where a reference agent executes a validated plan simultaneously to produce real-time reference outputs. Experiments show that even frontier LLMs achieve a success rate below 60\%, highlighting challenges in multi-step tool use. Comprehensive error analysis identifies seven failure modes spanning tool planning, parameterization, and output handling, pointing to concrete directions for improving current models. LiveMCP-101 sets a rigorous standard for evaluating real-world agent capabilities, advancing toward autonomous agent systems that reliably execute complex tasks through MCP tool orchestration.
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Integrative fragmentomic and mutational signature profile of plasma cfDNA for early lung cancer detection

NPJ Precis Oncol. 2026 Apr 15. doi: 10.1038/s41698-026-01416-y. Online ahead of print.

ABSTRACT

Detecting lung cancer effectively in the general population is essential for optimizing treatment outcomes and improving the 5-year survival rate. While low-dose computed tomography (LDCT) is the current standard, it has limitations in broader populations. We developed a blood-based multi-omics model using whole-genome cell-free DNA (cfDNA) features to distinguish lung cancer from non-cancer individuals. This study included 1600 patients and an equal number of non-cancer controls, divided into training and validation cohorts. The model achieved an area under the curve (AUC) of 95.59% for the training cohort and 95.74% for the validation cohort. The model consistently performed well across various cancer stages and histological subtypes. To further validate the performance of the model, an external validation cohort was utilized. Notably, it also effectively differentiated non-cancer samples from cancer samples in the external validation cohort, with 85.9% sensitivity and 94.78% specificity. Importantly, in simulated population screenings, our ctDNA assay outperformed both LDCT and a previously established method. This suggests its potential utility in wider lung cancer screening programs, possibly complementing the LDCT approach. In conclusion, our ctDNA assay emerges as a promising and highly sensitive tool for the early detection and categorization of lung cancer.

PMID:41986614 | DOI:10.1038/s41698-026-01416-y

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Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription

Oncogene, Published online: 02 April 2026; doi:10.1038/s41388-026-03761-5

Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription
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ELLMob: Event-Driven Human Mobility Generation with Self-Aligned LLM Framework

arXiv:2603.07946v1 Announce Type: cross Abstract: Human mobility generation aims to synthesize plausible trajectory data, which is widely used in urban system research. While Large Language Model-based methods excel at generating routine trajectories, they struggle to capture deviated mobility during large-scale societal events. This limitation stems from two critical gaps: (1) the absence of event-annotated mobility datasets for design and evaluation, and (2) the inability of current frameworks to reconcile competitions between users' habitual patterns and event-imposed constraints when making trajectory decisions. This work addresses these gaps with a twofold contribution. First, we construct the first event-annotated mobility dataset covering three major events: Typhoon Hagibis, COVID-19, and the Tokyo 2021 Olympics. Second, we propose ELLMob, a self-aligned LLM framework that first extracts competing rationales between habitual patterns and event constraints, based on Fuzzy-Trace Theory, and then iteratively aligns them to generate trajectories that are both habitually grounded and event-responsive. Extensive experiments show that ELLMob wins state-of-the-art baselines across all events, demonstrating its effectiveness. Our codes and datasets are available at https://github.com/deepkashiwa20/ELLMob.
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CM2: Reinforcement Learning with Checklist Rewards for Multi-Turn and Multi-Step Agentic Tool Use

arXiv:2602.12268v2 Announce Type: replace Abstract: AI agents are increasingly used to solve real-world tasks by reasoning over multi-turn user interactions and invoking external tools. However, applying reinforcement learning to such settings remains difficult: realistic objectives often lack verifiable rewards and instead emphasize open-ended behaviors; moreover, RL for multi-turn, multi-step agentic tool use is still underexplored; and building and maintaining executable tool environments is costly, limiting scale and coverage. We propose CM2, an RL framework that replaces verifiable outcome rewards with checklist rewards. CM2 decomposes each turn's intended behavior into fine-grained binary criteria with explicit evidence grounding and structured metadata, turning open-ended judging into more stable classification-style decisions. To balance stability and informativeness, our method adopts a strategy of sparse reward assignment but dense evaluation criteria. Training is performed in a scalable LLM-simulated tool environment, avoiding heavy engineering for large tool sets. Experiments show that CM2 consistently improves over supervised fine-tuning. Starting from an 8B Base model and training on an 8k-example RL dataset, CM2 improves over the SFT counterpart by 8 points on tau^-Bench, by 10 points on BFCL-V4, and by 12 points on ToolSandbox. The results match or even outperform similarly sized open-source baselines, including the judging model. CM2 thus provides a scalable recipe for optimizing multi-turn, multi-step tool-using agents without relying on verifiable rewards. Code provided by the open-source community: https://github.com/namezhenzhang/CM2-RLCR-Tool-Agent.
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RewardMap: Tackling Sparse Rewards in Fine-grained Visual Reasoning via Multi-Stage Reinforcement Learning

arXiv:2510.02240v2 Announce Type: replace-cross Abstract: Fine-grained visual reasoning remains a core challenge for multimodal large language models (MLLMs). The recently introduced ReasonMap highlights this gap by showing that even advanced MLLMs struggle with spatial reasoning in structured and information-rich settings such as transit maps, a task of clear practical and scientific importance. However, standard reinforcement learning (RL) on such tasks is impeded by sparse rewards and unstable optimization. To address this, we first construct ReasonMap-Plus, an extended dataset that introduces dense reward signals through Visual Question Answering (VQA) tasks, enabling effective cold-start training of fine-grained visual understanding skills. Next, we propose RewardMap, a multi-stage RL framework designed to improve both visual understanding and reasoning capabilities of MLLMs. RewardMap incorporates two key designs. First, we introduce a difficulty-aware reward design that incorporates detail rewards, directly tackling the sparse rewards while providing richer supervision. Second, we propose a multi-stage RL scheme that bootstraps training from simple perception to complex reasoning tasks, offering a more effective cold-start strategy than conventional Supervised Fine-Tuning (SFT). Experiments on ReasonMap and ReasonMap-Plus demonstrate that each component of RewardMap contributes to consistent performance gains, while their combination yields the best results. Moreover, models trained with RewardMap achieve an average improvement of 3.47% across 6 benchmarks spanning spatial reasoning, fine-grained visual reasoning, and general tasks beyond transit maps, underscoring enhanced visual understanding and reasoning capabilities.
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Privacy-Concealing Cooperative Perception for BEV Scene Segmentation

arXiv:2602.13555v1 Announce Type: cross Abstract: Cooperative perception systems for autonomous driving aim to overcome the limited perception range of a single vehicle by communicating with adjacent agents to share sensing information. While this improves perception performance, these systems also face a significant privacy-leakage issue, as sensitive visual content can potentially be reconstructed from the shared data. In this paper, we propose a novel Privacy-Concealing Cooperation (PCC) framework for Bird's Eye View (BEV) semantic segmentation. Based on commonly shared BEV features, we design a hiding network to prevent an image reconstruction network from recovering the input images from the shared features. An adversarial learning mechanism is employed to train the network, where the hiding network works to conceal the visual clues in the BEV features while the reconstruction network attempts to uncover these clues. To maintain segmentation performance, the perception network is integrated with the hiding network and optimized end-to-end. The experimental results demonstrate that the proposed PCC framework effectively degrades the quality of the reconstructed images with minimal impact on segmentation performance, providing privacy protection for cooperating vehicles. The source code will be made publicly available upon publication.
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